Oncology
U.S. Senator Barbara Boxer (D-CA) introduced the National Nursing Reform and Patient Advocacy Act, legislation to protect the rights of nurses to advocate on behalf of their patients, set minimum nurse-to-patient ratios in hospitals, and invest in training nurses to address the current nationwide nursing shortage.
A combination of measures taken to improve nutrition, indoor air pollution, immunization and child pneumonia case management could reduce total child mortality worldwide by 17 percent and global pneumonia deaths by more than 90 percent, according to a study published in the June issue of the Bulletin of the World Health Organization, UPI reports.
U.S House Majority Leader Steny Hoyer (D-Md.) on Wednesday expressed skepticism that Congress would approve President Obama"s recent request for an additional $2 billion to help fight the H1N1 (swine flu) virus, Reuters/Washington Post reports.
Tamiflu
The Michigan Department of Community Health recently received approval from state lawmakers to use $3.2 million in private funds to support the state"s AIDS Drug Assistance Program, the AP/Detroit News reports. Michigan"s House and Senate Appropriations Committees also approved requests by other state agencies to shift funds as a means to continue public programs that were affected by budget cuts ordered last month (Eggert, AP/Detroit News, 6/4).
It takes less than a minute for a stroke to change a person"s life forever, but taking the time to make a few simple lifestyle adjustments and finding out how to recognize an attack when it happens can save thousands of lives.
NewYork-Presbyterian Hospital/Columbia University Medical Center physician-scientists presented new research at the 2009 American Transplant Congress in Boston, May 30 to June 3. Topics included minimizing steroid exposure for liver transplant patients with hepatitis C; hypothermic machine perfusion vs. cold storage for preserving donor livers; and the effectiveness of neutrophil-lymphocyte ratio in predicting colorectal liver metastases in liver cancer patients undergoing transplantation.
The first of six online courses to educate healthcare professionals on preventing the transmission of healthcare-associated infections (HAIs) is being launched by the Association for Professionals in Infection Control and Epidemiology (APIC). Healthcare-associated infections (HAIs) cause 99,000 deaths in the U.S. each year.
Adding AZD3355, a novel GABAB receptor agonist, to a proton pump inhibitor (PPI) in patients with Gastroesophageal Reflux Disease (GERD), resulted in a 35% reduction in the mean total number of reflux episodes 0-24 hours after dose, compared with placebo.[i] These data were presented at the Digestive Diseases Week annual meeting (DDW®, 30 May - 4 June, Chicago).
Improvements in diagnosis and treatment over the past 30 years have led to a 17% decrease in the likelihood of death from aneurysmal subarachnoid haemorrhage (the bursting of a blood vessel on the surface the brain) in the general population, according to an Article published Online First and in the July edition of The Lancet Neurology.
Pfizer Animal Health today announced that the U.S. Food and Drug Administration (FDA) has approved the first canine cancer therapy in the U.S. - PALLADIATM (toceranib phosphate) - which was developed by Pfizer to treat mast cell tumors in dogs. Pfizer made the announcement to veterinarians attending the 2009 American College of Veterinary Internal Medicine (ACVIM) Forum and Canadian Veterinary Medical Association Convention.
Disc Dynamics, Inc., a leading developer of minimally invasive treatment options for low back pain caused by degenerative disc disease (DDD), announced that the CE Mark received in the European Union for its DASCOR® Disc Arthroplasty System has been expanded to incorporate a posterior-lateral surgical approach, as well as an endoscopic approach.
GfK Healthcare"s Roper Global Diabetes Program, the definitive global perspective on diabetes, announced today the launch of its enhanced U.S. Diabetes Patient Market Study. Through a modular approach and with tailored reporting, the study offers health care and related companies in the diabetes category access to patient data and market trends from one of the largest surveys of people with diabetes, and the only one projectable to the U.S. population.
"With a continuously ageing population the incidence of osteoporosis is steadily rising. This does not only pose problems to the individuals concerned but is also an enormous challenge for our societies" according to Professor Wolfhart Puhl, past president of the European Federation of National Associations of Orthopaedics and Traumatology (EFORT). Prof. Puhl, of the Orthopç¤dikum Allgç¤u, Germany, who is in Vienna for the EFORT Congress, emphasized that the problem"s "dimension is frequently underestimated. Policy makers and funding agencies do not always consider this development sufficiently in their planning."
New standards to improve access to diagnosis and treatment of sarcomas have been published by the Welsh Assembly Government.
A new study of Chinese-American youth has found that family obligation, for example caring for siblings or helping elders, plays a positive role in the mental health of Chinese-American adolescents and may prevent symptoms of depression in later teenage years.
Cigarette smoking induced COPD, or chronic obstructive pulmonary disease, is a disease that results in severe breathing difficulty. According to World Health Organization (WHO) it is the fourth leading killer worldwide. However the mechanisms responsible for some smokers developing COPD and others evading the disease have not been well understood.
Cervical Cancer Awareness Week 8-14 June 2009 is a key time to remind women that it is of huge importance that they attend their screening appointment when asked. The Improvement Foundation (IF) aim to help tackle the decline in screening uptake by addressing levels of complacency among clinicians and the public through their national Cervical Screening Improvement Programme.
An Australian psychiatrist believes Britain"s stiff upper lip culture, class system and the NHS means we are not supporting the mental health needs of war veterans adequately.
The NHS Institute for Innovation and Improvement launches its first National Innovation and Improvement Survey. Created in partnership with strategic health authorities, the survey offers all NHS staff in the UK an opportunity to influence the national innovation agenda.
Two-thirds of patients are happy for their medical records to be stored electronically, according to a snapshot survey carried out in a community mental health setting. But many patients still have concerns about security and confidentiality.
Agricultural Research Service (ARS) scientists have sequenced the genome
Clinical trial results presented today at the American Diabetes Association annual meeting show that overall rates of cardiovascular hospitalization and cardiovascular death are similar in patients taking Avandia (rosiglitazone) compared to those receiving metformin and sulfonylurea.
The Juvenile Diabetes Research Foundation International, the world"s leading charitable funder and advocate of diabetes research, said that it is partnering with Sanford Health, an integrated health care system in South Dakota and the Midwest, in an innovative "cure collaboration" to speed the pace of diabetes research and delivery of cures at the point-of-care.
A new Faculty of Translational Medicine has been launched to increase support for, and enhance collaboration among researchers as they search for new treatments and diagnostic tests for a range of diseases and conditions. The Faculty is based in the National Institute for Health Research Comprehensive Biomedical Research Center at Guy"s and St Thomas" hospitals and King"s College London.
CSIRO and a local water authority in Queensland, SEQWater, have joined forces to monitor the Lake Wivenhoe catchment, which spans an area about the size of the city of Brisbane, and supplies water to the region"s 1.5 million residents.
"As the debate on how to fix health care picks up pace, so does discussion about one of the most lucrative ways to pay for it:" taxing employer-provided health benefits, CNN reports. The "tax-free arrangement" in which an employer"s contribution to employee health benefit "is treated as tax-free to the employee in terms of income tax and payroll tax," was "born during the days of wage control in 1943." According to Paul Fronstin, director of the health research program at the Employee Benefit Research Institute, employers were not allowed to "attract workers on the basis of better pay," so instead they offered the benefits "as a way to compete for the best talent." Over the past 66 years, employees have come to expect it. But "tax and health experts say it"s inequitable. High-income workers and those with the most expensive health insurance plans enjoy the biggest break as a result of the tax exclusion."
The transition from basic education to upper secondary school is a challenge for many young people. According to a study of school burnout at different stages of school and higher education, upper secondary school is a particularly challenging stage for many young people. Success-oriented female upper secondary school pupils are at the greatest risk: up to 20 cent of them suffer from school burnout. Burnout is a phenomenon to be taken seriously, as it can lead to depression.
The Office of the National Coordinator for Health Information Technology"s number-two man, Charles Friedman, told industry members that an official definition of the term "meaningful use" of health information technology is "in the works" and they should expect its release "in the not too distant future." "Meaningful use" refers to the criteria the government will use to determine whether to pay providers for adopting the technology, Modern Healthcare reports.
As state revenues continue their downturn due to the recession, 16 states are trying to find ways to deal with increased health care costs, The New York Times reports: "The carnage in state budgets is getting worse, a report said Thursday, with places like Arizona being hurt by falling revenue on multiple fronts, like personal income and sales taxes. Other states are having mixed experiences, with some tax categories stable, or even rising, even as others fall off the map."
UroToday.com - The prevailing view is that MRI has a limited role in the management of prostate cancer. Currently, the threshold for requesting a pre-treatment staging MRI is variable with most advocating this for only those classified as high risk localized prostate cancer, although some also advocate men with intermediate risk disease.
The results of the LEAD-6 study are published in an article Online First and in a future edition of The Lancet. The findings are presented at the same time at the American Diabetes Association meeting in New Orleans, USA. They indicate that taking liraglutide once a day is more efficient in controlling blood glucose in type 2 diabetes than the presently marketed treatment - two doses a day of exenatide.
Results from a number of clinical trials were presented during the Digestive Disease Week (DDW) in Chicago this week, revealing new outcomes data related to endoscopic radiofrequency ablation using the HALO ablation system for eradicating a pre-cancerous esophageal condition known as Barrett"s esophagus. Among them, reports included durability outcomes from a randomized sham-controlled trial, safety and efficacy outcomes from a large U.S. registry of 429 patients, a randomized trial comparing ablation to endoscopic resection, and the largest European series to date in patients with high-grade dysplasia and early cancer.
Idaho Technology, Inc. has received the support of the U.S. Army Test and Evaluation Command (ATEC) for use of the Platinum Path™ Extraction Kit (PPEK) with the Joint Biological Agent Identification and Diagnostic System (JBAIDS).
Cobalis Corporation (OTC:CLSC) was recently awarded two additional International Patents in Canada and Mexico and has a patent pending application in Japan. PreHistin® is patented, safe for long-term daily use and available without a prescription. It is available in a cherry flavored, all natural, proprietary cyanocobalamin (vitamin B12) sub-lingual lozenge that is taken twice daily to regulate allergy sufferers" response to both indoor and outdoor allergens with daily and year round usage.
Lantheus Medical Imaging, Inc., a worldwide leader in diagnostic imaging, announced today that the company"s leading imaging agent, Cardiolite® (Kit for the Preparation of Technetium Tc99m Sestamibi for Injection), was used in a recently completed five-year study examining appropriate treatment regimens for patients with type 2 diabetes and coronary artery disease. The results of this study, known as The Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D), will be presented by the University of Pittsburgh Graduate School of Public Health at a special symposium on Sunday, June 7, 2009, from 4:15 p.m. - 5:15 p.m. (CT) at the American Diabetes Association 69th Scientific Sessions in New Orleans.
More than 1,500 registered dental hygienists (RDH) from across the United States will travel to Washington D.C. to attend the 86th Annual Session of the American Dental Hygienists" Association (ADHA) June 17-23.
AARP Executive Vice President John Rother issued the
Standards of Care Survey shows that over a third of all parents of children living with Duchenne feel that their child receives sub-standard medical care.
The United Nations World Food Programme (WFP) is streaming
There is no difference in mortality among patients with type 2 diabetes and stable heart disease who received prompt bypass surgery or angioplasty compared to drug therapy alone, according to a landmark study focused exclusively on patients with both conditions. The study, which was led by investigators at the University of Pittsburgh Graduate School of Public Health, published in the June 11 issue of the New England Journal of Medicine and presented at the American Diabetes Association 69th Scientific Sessions, also found that while prompt bypass in patients with more severe heart disease did not lower mortality, it lowered their risk of subsequent major cardiac events.
The National Audit Office (NAO) on Friday released findings from a new report exploring the problems and challenges of supporting adults with autism. The aim of the report was to assess current service provision in areas including: health, social care, education, benefits and employment support. It also identified how these areas could be made more effective, efficient and appropriate to the needs of adults with autism and their carers.
Tolerx, Inc., a biopharmaceutical company engaged in the discovery and development of novel therapies for immune-mediated diseases, presented results from a pre-clinical dose-optimization study conducted with a surrogate of its Phase 3 anti-CD3 monoclonal antibody, otelixizumab, at the 69th Scientific Sessions of the American Diabetes Association (ADA), which is continuing until June 9, 2009 in New Orleans, Louisiana.
A study in the June issue of Clinical Gastroenterology and Hepatology, published by Elsevier, demonstrates that the Hepascore(TM) liver fibrosis blood-serum test panel may help physicians more accurately diagnose and stage liver fibrosis in patients with chronic hepatitis C (HCV), potentially alleviating the need for liver biopsy, the standard of care for staging fibrosis, in a particular subset of patients. The Hepascore test panel is provided exclusively by Quest Diagnostics Incorporated (NYSE: DGX), the world"s leading provider of diagnostic testing, information and services.
New Phase II data presented at the American Diabetes Association 69th Scientific Sessions in New Orleans show that the investigational type 2 diabetes treatment Syncria(R) (albiglutide) significantly reduced blood glucose levels and provided weight loss across weekly, biweekly and monthly dosing. Reducing blood sugar is a key part of managing type 2 diabetes, a disease that affects over 250 million people worldwide.
At a June 12 forum cosponsored by Health
The Casper Star-Tribune profiled Carol Fischer and Mark Dowell, the only two physicians in southeastern Wyoming that treat large numbers of people with HIV. There are more than 100 people in Wyoming living with HIV, according to the state Department of Health, and Fischer and Dowell treat most of them, the Star-Tribune reports. Fischer has been deemed the "de facto AIDS doctor" in the area as she received no formal training on HIV, but Dowell is an expert on the disease who became the state"s first full-time infectious disease specialist (Miller, Casper Star-Tribune, 6/7).
Industry groups reacted "warily" this weekend to a draft of the Senate HELP (Health, Education, Labor and Pensions) Committee"s health overhaul plan. The first details emerged late Friday and lobbyists began speaking up, USA Today reports:
Michigan"s Medicaid program is growing by as many as 15,000 people a month, but fewer physicians are accepting new patients insured by the program, which physicians say pays too little to cover their costs, the Associated Press reports. Meanwhile, the Michigan governor"s office announced an additional 4 percent cut last month, which "will lower payments across the board for hospitals, dentists and doctors who treat Medicaid patients." The article notes that in Michigan, the program currently insures a record 1.6 million residents.
U.S. Attorney General Eric Holder and Congress "should review the killing" of Kansas abortion provider George Tiller "to determine whether there are systemic problems that led to apparent gaps in the FBI"s performance in the case," a New York Times editorial states. According to the Times, Holder "took the prudent step of ordering" the U.S. Marshals Service to "provide security for certain abortion clinics and physicians thought to be at heightened risk," but the government"s response "must not end there."The editorial states that Scott Roeder, the man accused of killing Tiller, has a history of activity related to the antiabortion-rights movement that "should have sparked greater concern" with the FBI, including being suspected in 2000 of "repeatedly gluing shut the doors of an abortion clinic in Kansas City, Kan. -- a federal crime under the 1994 Freedom of Access to Clinic Entrances law." Roeder also was found in possession of "gunpowder and a fuse" when stopped for a traffic violation in 1996, according to the Times. The editorial states, "In the past, Tiller was shot in both arms, and his clinic was bombed and vandalized," but "it seems as if the federal authorities failed to increase security for Dr. Tiller and his offices."The editorial continues, "An armed criminal bent on murder is hard to stop, and we do not blame the FBI for Dr. Tiller"s death." However, "reproductive rights advocates say enforcement of the clinic protection law waned in the Bush years," the editorial says, concluding that Holder "should make sure there is no underlying problem that inhibits efforts to combat intimidation and violence against the dwindling number of legal abortion providers -- and women they help" (New York Times, 6/8).
A study available ahead of print in Tobacco Control reports that the cost of tobacco illnesses to the National Health Services in The United Kingdom is five times the accepted figure, resulting in more than 5 billion pounds a year.
A team of researchers sponsored by three major international diabetes organizations has definitively established that the GlycoMark® test (1,5-AG), a simple blood test used to measure glucose control in patients with diabetes, accurately reveals potentially dangerous fluctuations in blood sugar that are undetectable by other means.
PanGenetics B.V. announced that the Competent Authority of the Netherlands has approved the Clinical Trials Application for a first-in-man study with antibody PG110. This humanized antibody is a member of the class of Nerve Growth Factor (NGF) inhibitors which represent a promising novel approach in the treatment of chronic pain. PG110 will be evaluated in patients suffering from pain caused by osteoarthritis (OA). The clinical trial is designed as a double blind, placebo controlled study and will be conducted in a single site in Utrecht, the Netherlands, in collaboration with Kendle International.
As National Blood Donor Week begins, Canadian Blood Services is calling on donors across the country to give the life-saving gift during the critical summer months and ensure that the national blood inventory remains at acceptable levels.
The woolly mammoth died out several thousand years ago, but the genetic material they left behind is yielding new clues about the evolution of mammals. In a study published online in Genome Research, scientists have analyzed the mammoth genome looking for mobile DNA elements, revealing new insights into how some of these elements arose in mammals and shaped the genome of an animal headed for extinction.
As the official sponsor of birthdays, the American Cancer Society announced new survey results that show people who say they are in excellent health enjoy better birthdays. The online survey of 2,002 U.S. adults, which demonstrated a strong link between health and attitudes about birthdays, revealed that people who say they are in excellent health are more likely to consider birthdays special and exciting events. In addition, people who say they are in excellent health are nearly twice as likely to love celebrating birthdays, generally consider them fun and feel more special on their birthday than people who say they are in poor health.
A chemotherapy drug that is supposed to help save cancer patients" lives, instead resulted in life-threatening and sometimes fatal allergic reactions.
Judges often make poor decisions about the stories asylum seekers tell them because their decisions are based on false assumptions.
CSIRO Food Futures National Research Flagship and Australian company Stadvis Pty Ltd have signed a worldwide license agreement to commercialise an automated instrument that accurately predicts glycemic index (GI) and resistant starch (RS) in food products.
A synthetic DNA binding compound has proved surprisingly effective at binding to the DNA of bacteria and killing all the bacteria it touched within two minutes. The DNA binding properties of the compound were first discovered in the Department of Chemistry at the University of Warwick by Professor Mike Hannon and Professor Alison Rodger (Professor Mike Hannon is now at the University of Birmingham). However the strength of its antibiotic powers have now made it a compound of high interest for University of Warwick researchers working on the development of novel antibiotics.
The results from the phase II SYNCHRONY study are published in an article Online First and in a future edition of The Lancet. At the same time, the findings are presented at the American Diabetes Association meeting in New Orleans, USA. They suggest that aleglitazar, a treatment for type 2 diabetes, might be safe and effective and may perhaps be introduced into phase III trials.
Methuselah Foundation has identified Organovo, Inc. as a leader in the extraordinary science of bio-printing. The US Department of Health and Human Services predicts: "Within 20 years regenerative medicine will be the standard of care for replacing all tissue/organ systems in the body." Organovo, with the support of Methuselah Foundation, is applying its breakthrough organ printing technologies to make that prediction a reality.
Arete Therapeutics Inc. announced the presentation of three posters that validate the mechanistic activity and therapeutic potential of the company"s lead drug candidate, AR9281, an orally-administered soluble epoxide hydrolase (sEH) inhibitor that is in a Phase II clinical program for the treatment of type 2 diabetes. sEH is an enzyme involved in the metabolism of arachidonic acid, a key signaling molecule implicated in diabetes, hypertension and inflammatory disorders.
DOR BioPharma, Inc. (DOR or the Company) (OTC Bulletin Board: DORB), a late-stage biopharmaceutical company, announced that it has received Protocol Assistance feedback from the European Medicines Agency (EMEA) on the design of its confirmatory, pivotal, Phase 3 clinical trial evaluating its lead product orBec(R) for the treatment of acute gastrointestinal Graft-versus-Host Disease (GI GVHD).
ISTA Pharmaceuticals, Inc. (Nasdaq: ISTA), announced positive results from a proof-of-concept Phase 2 clinical study in subjects with dry eye disease (keratoconjuctivitis sicca) using a new, proprietary, low-dose formulation of bromfenac, the active ingredient in Xibrom(R) (bromfenac ophthalmic solution) 0.09%. The study achieved statistical significance in the primary endpoint of the objective sign of conjunctival staining (Lissamine Green test) as compared to baseline. The study also achieved statistical significance on the objective sign of corneal staining (Fluorescein test) as compared to baseline. Patients also achieved statistically significant improvements in subjective symptoms measured by the Ocular Surface Disease Index (OSDI) and improvement in patients" most bothersome ocular symptoms.
Unilever and the World Heart Federation announce a joint initiative to promote awareness of Heart Age - a new, personally motivating way of expressing an individual"s risk of developing heart disease and stroke.
According to the American Cancer Society, colorectal cancer, America"s third leading type of cancer, is also one of the most preventable. One-third of all colorectal cancer deaths could be avoided by simple screening, they say. But colonoscopies, though highly effective, can also be painful, and current diagnostic techniques are time-consuming and sometimes inaccurate.
The Escambia County Health Department established a mosquito control program in 2008 that
More than 3,300 primary care providers nationwide will be eligible for approximately $200
High-quality one-stop breast clinics could be the most effective way to spot breast cancer early, a study published in the British Journal of Cancer * reveals today (Wednesday).
A recent study found developing countries affected by war receive less money for reproductive health than other developing nations, despite having acute needs, Reuters reports. "In war-affected countries, 1,041 pregnant women die for every 100,000 live births due to complications such as bleeding, infections and obstructed labour" compared to 720 maternal deaths for every 100,000 live births in "underdeveloped countries that were unaffected by war," Reuters writes. Nine women die for every 100,000 live births "in advanced countries with modern healthcare facilities," according to Reuters.
Low blood glucose levels do not explain the excess deaths seen in the intensive control group of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, according to a report presented here today at the American Diabetes Association"s 69th Scientific Sessions.
A Selection of Editorials and Opinions
Boys who carry a particular variation of the gene Monoamine oxidase A (MAOA), sometimes called the "warrior gene," are more likely not only to join gangs but also to be among the most violent members and to use weapons, according to a new study from The Florida State University that is the first to confirm an MAOA link specifically to gangs and guns.
In response to a study, funded by the British Heart Foundation and published online by Tobacco Control Journal , Betty McBride, Policy & Communications Director, at the British Heart Foundation, said:
Quality, in addition to quantity, is important for maintaining health, according to a research abstract that will be presented on Wednesday, June 10, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies.
Three researchers from the Virginia Bioinformatics Institute (VBI) at Virginia Tech have developed and evaluated a new one-step bioanalytical approach that allows them to profile in detail complex cellular extracts of proteins. The method has allowed the scientists to look at how the levels of proteins change in breast cancer cells when they are treated with hormones or cancer drugs like tamoxifen.
Almost three-quarters (74%) of people providing unpaid care for a loved
U.S. Health and Human Services (HHS) Secretary Kathleen Sebelius today released a new report on health disparities in America and participated in a White House Health Care Stakeholder Discussion on the importance of reform that reduces disparities that exist in our current health care system. The new report Health Disparities: A Case for Closing the Gap is available at http://www.HealthReform.gov.
Don"t feel like you are getting full when eating a large meal? New research from The Miriam Hospital suggests that a physiological response may partially explain why severely obese individuals may not feel satisfied after eating and often have difficulty controlling the amount of food they consume during a meal.
A leading anxiety charity has today criticised Veteran Labour MP Sir Gerald Kaufman for using Obsessive-Compulsive Disorder as an excuse for, by his own admittance "bizarre and daft" MP expense claims.
Botox is well known for its cosmetic uses, but researchers have now found that it can also significantly improve people"s quality of life if they suffer from another problem that increases with age, an overactive bladder (OAB).
Lack of Association Between Autoimmune Antibodies and Improved Outcome in Melanoma Patients
New research from Jefferson Hospital for Neuroscience (JHN) may redefine how Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is diagnosed. Eduardo De Sousa, M.D., assistant professor of Neurology at Jefferson Medical College of Thomas Jefferson University, and director of the Electrodiagnostic Neuromuscular Lab at JHN, led the study which looked at the number of demyelinating features that are needed to differentiate between CIDP, Amyotrophic lateral sclerosis (ALS, or Lou Gehrig"s disease) and diabetic neuropathy. His research suggests a minimum number of three demyelinating features can be used to positively identify CIDP in a patient. CIDP is a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. It affects about 50,000 people in the United States. The study, available in the current edition of the Journal of Clinical Neuromuscular Disease, may help doctors more effectively diagnose and treat CIDP.
The Royal Society for Public Health (RSPH) announces it will be delivering training sessions for the RSPH Level 1 Health Awareness and the RSPH Level 2 Understanding Health Improvement awards.
New data presented at the American Diabetes Association (ADA) 69th Annual Scientific Sessions showed that initial treatment with "Janumet"* (sitagliptin/metformin) provided significantly greater blood sugar improvements in drug-naç¯ve** patients with type 2 diabetes, compared with metformin alone.[i]
In a study that sheds light on how insurance coverage may drive health care and may reveal an unexpected result for the uninsured, a team of Yale School of Medicine and Yale-New Haven Children"s Hospital physicians has found that babies from uninsured families who are born with congenital defects are far more likely than those whose families have insurance to be transferred out of the large community hospitals where they are born and into children"s hospitals for corrective surgery.
The Automation Partnership (TAP), a world leader in the design and development of innovative advanced automation for life science applications, announced it is collaborating with world leading academics on the prestigious, Technology Strategy Board funded, RAFT (Rapid Automated Fabrication of Tissues) Project to develop and commercialise novel technology for rapid production of 3D tissues, which have the potential to transform drug discovery and regenerative medicine.
Researchers at McGill University and the affiliated Lady Davis Institute for Medical Research at Montreal"s Jewish General Hospital - along with colleagues at the University of Manitoba and the University of British Columbia - may have found a chink in the armour of the human immunodeficiency virus type 1 (HIV-1), the microorganism which causes AIDS. They have pinpointed the key cellular machinery co-opted by HIV-1 to hijack the human cell for its own benefit. Their study was published in May in the Journal of Biological Chemistry.
Versartis, Inc., an emerging company developing novel biologics with enhanced properties for patients with metabolic diseases, presented data for its long-acting product candidates, VRS-317 (hGH-rPEG) for treatment of growth hormone deficiency and for VRS-826 (IL-1ra-rPEG) for treatment of type 1 and type 2 diabetes, at the Endocrine Society"s Annual Meeting in Washington, DC.
NeurogesX, Inc. (Nasdaq: NGSX) announced that the U.S. Food and Drug Administration (FDA) agreed to its proposed study to evaluate Qutenza(TM) in patients with post-herpetic neuralgia (PHN) following pretreatment with an FDA-approved topical anesthetic. As part of its ongoing new drug application (NDA) review, the FDA wants to determine whether pretreatment with an FDA-approved topical anesthetic would provide similar tolerability to the topical agent used as a pretreatment in the clinical development program.
The Senate Finance Committee and the House Energy and Commerce Committee on Thursday both worked on health care proposals aimed at overhauling the U.S. health care system, CQ Today reports. In its second of three closed-door meetings, the Finance Committee came to "early, broad agreement" on some issues but continued to disagree over a public option as part of a reform bill. Meanwhile, portions of an overhaul plan being developed by the Energy and Commerce Committee were leaked on Thursday, after Democrats on the committee held a closed-door session on the topic earlier this week (Armstrong, CQ Today, 5/14). Finance Committee
The Senate Appropriations Committee on Thursday voted unanimously to approve a $91.3 billion defense and foreign aid spending bill that includes President Obama"s request for $1.5 billion in emergency funds to fight a potential influenza pandemic, the AP/Winston-Salem Journal reports. The House version of the bill, approved Thursday in a 368-60 vote, adds $500 million to the pandemic preparedness funds (AP/Winston-Salem Journal, 5/15). Last month, the public health emergency involving the H1N1 influenza virus spurred congressional lawmakers to rethink the elimination of $870 million from the economic stimulus package that would have been used to combat an influenza pandemic. Democratic legislators eliminated the funds in order to garner support from congressional Republicans to pass the stimulus package (Kaiser Daily Health Policy Report, 4/28).
UNAIDS Executive Director Highlights Latin America, Caribbean Successes In Battle Against HIV/AIDS
It"s June, the month when many couples promise to stay together "in sickness and in health."
Washington state lawmakers this week eliminated a budgetary proposal that would have reduced Medicaid payment rates to pharmacies to the lowest levels in the country, the AP/Spokane Spokesman-Review reports. The provision would have reduced the payment rate from 86% to 80% of the average wholesale price of branded drugs. It had been approved by the state House and Gov. Chris Gregoire (D) and was intended to address the state"s $9.3 billion shortfall for the current fiscal year.The state"s Department of Social and Health Services moved to make the rate change on April 1, but pharmacy operators and a person living with HIV/AIDS brought a suit in federal court in Tacoma, Wash., and a judge blocked the change. According to the judge"s order, the plaintiffs likely could prove that their best interests had not been sufficiently considered and that the proposal would diminish the quality of Medicaid care in the state. Walgreen had stated that if the rate change occurred, 44 of its 111 stores in the state would no longer be able to fill Medicaid prescriptions. Other pharmacies made similar arguments. The state prepared an argument on behalf of the rate cut, but later decided against it.Along with eliminating the payment reduction, state legislators added a provision that a DSHS analysis is required before rates can be lowered in the next budget, as well as one placing a 2% cap on any future rate cuts. DSHS spokesperson Jim Stevenson said the agency had not started to analyze what would be required to get a rate cut approved, but added, "I think we"re at a stage where we"re going to have to do it soon if we want to get ready for July 1," the start of fiscal year 2010 (AP/Spokane Spokesman-Review, 5/13).
A team of scientists in the US suggested that bisphenol A (BPA) may harm the heart, particularly in women, because of what they discovered in tests
The family of murdered Kansas abortion provider George Tiller announced on Tuesday that his Wichita clinic will not re-open, leading some abortion-rights advocates to voice concern about access to the procedure, the New York Times reports. Tiller was one of a handful of abortion providers who performed the procedure in the second and third trimesters of pregnancy, and women for decades have traveled to the clinic from across the U.S. and other countries. The clinic, Women"s Health Care Services, also was Kansas" only clinic outside the Kansas City area (Davey, New York Times, 6/10). The Tiller family said in a statement that the clinic will be "permanently closed" effective immediately. The family also said it does not plan to be involved "in any similar clinic" but will "honor Dr. Tiller"s memory through private charitable activities" (Slevin/Stein, Washington Post, 6/10).While abortion-rights advocates expressed empathy for the family, some added that they also are concerned that the clinic"s closure could have devastating effects for women who learn of fatal health problems late in their pregnancies, the Times reports. Nancy Northup, president of the Center for Reproductive Rights, said, "It is unacceptable that antiabortion intimidation and violence has led to the closing of Dr. Tiller"s clinic." She added, "Not only have we lost a fearless defender of women"s fundamental health and rights in Dr. Tiller"s murder, but the closing of his clinic leaves an immediate and immense void in the availability of abortion" (New York Times, 6/10). Suzanne Poppema, board chair of Physicians for Reproductive Choice and Health and a retired ob-gyn who performed abortions, said that abortions later in pregnancy would still be available, including through university hospitals that do not advertise the service. The closing is "not going to stop people who want to provide the service, but it will slow them down," she said. Marla Patrick, Kansas coordinator for the National Organization for Women, said abortion-rights advocates are working to open another Wichita-based clinic that provides abortions later in pregnancy (Bello, USA Today, 6/10). The AP/Yahoo! News reports that Kansas state law permits abortion after 21 weeks" gestation only if continuing the pregnancy would endanger the woman"s life or cause a "substantial and irreversible impairment" of a major bodily function, which courts have interpreted to include the mental health of the woman (Hegman/Hanna, AP/Yahoo! News, 6/9).According to the Times, some abortion-rights advocates had hoped other abortion providers would take over Tiller"s work at the clinic. LeRoy Carhart, a Nebraska abortion provider who also worked with Tiller, said he is "currently exploring every option to be able to continue to make second- and early, medically indicated third-trimester abortions available." Warren Hern, a Colorado abortion provider who performs procedures later in pregnancy, said, "Where does it end? The antiabortion fanatics got exactly what they wanted" (New York Times, 6/10). According to the Wall Street Journal, abortion-rights opponents" response to the closure was "subdued." Some expressed concern that antiabortion-rights extremists would think that violence "gets results where legal protest doesn"t," the Journal reports (Simon, Wall Street Journal, 6/10). Troy Newman, president of Operation Rescue, said that while the group is "thankful" that the clinic is closed, they "wish it would have come through the peaceful, legal channels that we were pushing" (New York Times, 6/10).Broadcast CoverageMSNBC"s "The Rachel Maddow Show" on Tuesday reported on the clinic"s closure and included a discussion with Susan Hill, president of the National Women"s Health Organization, about violence against abortion providers and an increase in the hostility of protesters outside abortion clinics since Tiller"s murder (Maddow, "The Rachel Maddow Show," MSNBC, 6/9). NPR"s "All Things Considered" on Tuesday also reported on the clinic"s closure ("All Things
Three faculty members from the University of Pittsburgh School of Nursing will be inducted as fellows into the American Academy of Nursing.
The war on healthcare associated infections (HCAIs), or so-called "superbugs", will never be won unless long-term strategies are introduced to radically reduce their prevalence, says a BMA report launched recently.
Physicians treating breast cancer first look to lymph nodes in a patient"s armpit to see whether cancer is spreading elsewhere in the body - but they may not be evaluating the nodes in the most effective way.
David Brooks, New York Times: Health care costs have become "the crucial issue of [President Obama"s] whole presidency," Times columnist Brooks writes. According to Brooks, Obama"s original plan was to fund his priorities, including education and energy, with debt that would be paid off with future savings resulting from health care reform. Brooks writes that Obama"s aides have been discussing "game-changers" -- such as health information technology, wellness programs, preventive medicine, comparative effective measures and altering reimbursement policies -- that would result in cost reductions. However, Brooks writes that most experts do not think such efforts would "produce much in the way of cost savings over the next 10 years" and that "nobody is sure" the efforts would "ever produce significant savings." Brooks writes that because "there are deep structural forces, both in Medicare and the private insurance market" that make it "nearly impossible to put together a majority coalition for a bill" challenging those structures, reform efforts this year likely will produce a "medium-size bill that expands coverage to some groups but does relatively little to control costs." Brooks concludes, "Without serious health cost cuts," Obama"s agenda "will hasten fiscal suicide" (Brooks, New York Times, 5/15).
Metoclopramide, a drug approved in the U.S. for nausea, vomiting and heartburn poses no significant risks for the fetus according to a large cohort study published in the June 11 issue of the prestigious New England Journal of Medicine, "The Safety of Metoclopramide Use in the First Trimester of Pregnancy" (N Engl J Med 2009;360:24 June 11, 2009).
A new drug being studied for the treatment of muscle degenerating diseases has shown promising results. According to a study published in the British Journal of Pharmacology, Debio 025 is as effective as current drugs but, crucially, does not cause unwanted immunosuppressive effects.
The following statistics were released by the Department of Health: Report on the experience of patients in Black and Minority Ethnic groups, based on data up to and including 2008 patient surveys. This report produced by the Department of Health with input and advice from the Care Quality Commission, examines variations in the self-reported views of NHS patients from different ethnic groups. Results are presented from the 2008/09 adult inpatient, 2008/09 emergency department, 2007/08 primary care services and 2007/08 community mental health patient surveys. These findings give us insight into the areas of NHS service provision where experience of the service looks different to patients from different ethnic groups. Results are based on data from the National Patient Survey programme, led by the Care Quality Commission.
A free, online lifestyle self-assessment service to help teenagers improve their health and wellbeing is being rolled out nationally by the Department of Health today.
Scientists have discovered exactly how some bacteria act to protect themselves when they are threatened or under attack.
Altus Pharmaceuticals Inc. (NASDAQ: ALTU) announced that patient dosing in its Phase 2 trial for ALTU-238 in growth hormone deficiency pediatric subjects began on June 2, 2009. ALTU-238 is a long-acting, extended-release formulation of recombinant human growth hormone (rhGH, somatropin), which is being developed utilizing Altus" proprietary protein crystallization technology. ALTU-238 is a ready-to-use liquid suspension of crystallized rhGH that preserves the structure of the rhGH molecule without the need for pegylation, polymerization, or encapsulation and enables administration through a fine gauge needle. The Phase 2 ALTU-238 pediatric trial is being conducted in approximately 18 clinical sites in the U.S. and targets enrolling 36 growth hormone deficient pediatric patients. ALTU-238 has been studied in a series of Phase 1 and Phase 2 studies in healthy and GH deficiency adults.
Colorectal cancer (CRC) is one of the most common cancers in China. Although the association between the epidemiological factors and sporadic colorectal cancer has been studied, the relation between smoking, alcohol drinking, family history of cancer, body mass index (BMI) and sporadic colorectal cancer still remains uncertain. So it is important to investigate the role of these factors in the development of sporadic colorectal cancer.
Human papillomavirus (HPV) is an important causative agent in squamous cell cancers of head and neck (HNSCC) a new meta-analysis presented at the American Society of Clinical Oncology (ASCO) confirms; but a separate European survey at the same meeting reveals the public is woefully ignorant about it and possible ways to avoid it. Lack of public awareness about the possible link between HPV-related head and neck cancer and oral sex with multiple partners presents a case for making vaccinations against HPV more widely available to boys as well as girls before they become sexually active, commented leading expert Professor Jean-Louis Lefebvre of Centre Oscar Lambret, Lille, France.
The value and cost-effectiveness of screening for left ventricular (LV) dysfunction remains unclear, particularly since specific, evidence-based treatments are not available for the majority of patients with preserved systolic dysfunction, reports a study in the June issue of the Journal of Cardiac Failure, published by Elsevier.
Hundreds of people gathered at a planned rally on Wednesday at the California State Capitol in Sacramento to protest the proposed $80.1 million in budget cuts to HIV/AIDS programs in the state, which would result in an 80 percent reduction in prevention, testing and counseling programs, as well as significant cuts in programs for people living with HIV, the San Francisco Chronicle reports. According to the Chronicle, the budget plan "faces pushback from the Legislature, where the leaders of both houses have announced their strong opposition," including Sen. Mark Leno (D). At the rally, Leno urged other lawmakers to examine the possible effects of the cuts. Lisa Page, a spokesperson for Gov. Arnold Schwarzenegger (R), said the governor understands the consequences of the cuts but the state is facing a $24.3 billion budget deficit and has limited options. She said, "Many of these cuts the governor would never consider except in a worst-case scenario, and this is the worst-case scenario" (Buchanan, San Francisco Chronicle, 6/11).