Mental Health
The results of an international study led by a Toronto-area doctor were unveiled today that show there"s a more effective way to treat patients with a severe arrhythmia, or irregular heartbeat, than the current treatment methods.
Human tissues normally discarded after surgical procedures could be a rich additional of stem cells for regenerative medicine. New research from BioMed Central"s open access Journal of Translational Medicine shows for the first time that human fallopian tubes are abundant in mesenchymal stem cells which have the potential of becoming a variety of cell types.
Researchers have identified a new candidate tumor suppressor gene in colorectal cancer and examined its use as a potential biomarker in stool samples, according to a new study published online June 17 in the Journal of the National Cancer Institute.
A $4.15 million, four-year National Institutes of Health grant will enable researchers at the Indiana University School of Medicine to conduct the first health study of teenage boys using cellular telephones.
There has been a recent questioning of the role of the limbal stem cell in corneal maintenance and the recent Association for Research in Vision and Ophthalmology (ARVO) meeting in Fort Lauderdale May 3 -7, 2009 saw some fairly hot debate son this topic. Professor Colin Green, University of Auckland, New Zealand reviews an interesting series of sessions for The Society for Clinical Ophthalmology.
Innocoll, Inc., a privately-held biopharmaceutical company, announced positive provisional findings from its three phase 2 clinical trials sponsored by its wholly owned subsidiary, Innocoll Technologies Ltd, to investigate CollaRx(R) GENTAMICIN TOPICAL for the treatment and prevention of infection in diabetic foot ulcers.
George Dahlman, senior vice president of public policy for The Leukemia & Lymphoma Society (LLS), testified today before the U.S. Senate Subcommittee on Defense Appropriations, calling for funding for a dedicated, stand-alone blood cancer research program at the Department of Defense (DoD).
According to a new report by HHS" Agency for Healthcare Research and Quality, there is insufficient evidence to conclude that genetic testing for two gene mutations in adults with a history of blood clots helps to prevent a condition known as deep-vein thrombosis or to improve other clinical outcomes.
The World Health Organization and UNICEF today called on governments to strengthen risk reduction measures in four key areas so that health and education systems are able to cope with disasters, including the risks from climate change. These are:
GENEART AG, global leader in gene synthesis and specialist in the field of Synthetic Biology, announces being awarded a contract for the design and production of two DNA vaccine candidates against HIV by the UK HVC. The genes (blueprints for virus proteins), optimized and customized by GENEART, are to be used as basis for clinical studies.
Our ability to form long-term memories depends on cells in the brain making strong connections with each other. Yet while it"s not well understood how those connections are made, lost or changed, the process is known to involve the movement of the AMPA receptor protein to and from those neuronal connections.
"Employers who offer health insurance coverage could see a 9 percent cost increase next year, and their workers may face an even bigger hit, according to a report Thursday from consulting firm PricewaterhouseCoopers," the Associated Press reports. Workers concerned about losing their jobs" and their insurance, while it lasts - are using more health care than usual, contributing to rising costs, the report says. As the costs increase, employers are also likely to shift more of the burden to employees. "A total of 42% of employers surveyed said they would increase employees" share of costs," the AP reports.
The Environmental Protection Agency on Wednesday declared its first-ever "public health emergency," asbestos contamination near Libby and Troy, Mont., northwestern mining towns, the Associated Press reports. "Asbestos contamination from a now-closed vermiculite mine has been cited in the deaths of more than 200 people and illnesses of thousands more. Before the vermiculite mine was closed in 1990, miners carried asbestos home on their clothes. Vermiculite once covered school running tracks in Libby and some residents used vermiculite as mulch in their home gardens."
The GOP Can Stop ObamaCare Wall Street Journal
The drugmaker Sanofi-Aventis will donate millions of doses of a vaccine that offers protection against the H1N1 (swine flu) virus to the WHO once the vaccine is ready, the company"s chief executive officer announced Tuesday, Reuters reports (Elsner, Reuters, 6/17). The AP/Google.com writes, "Exceptional times require exceptional responses. We need to act responsibly and we all have to play our part," Sanofi CEO Christopher Viehbacher said in a statement released during the Pacific Health Summit in Seattle. "This flexible donation aims to help the WHO address the needs of these most vulnerable populations," he said.
The Ugandan ministry of health said that everyone in the country will receive free insecticide-treated nets (ITNs) to prevent malaria beginning in September, James Kakooza, the state minister for primary health care, said, New Vision/allAfrica.com reports. Kakooza said children and mothers will be the priority, but that the goal is to make the 17.4 million imported ITNs available to everyone. The ITNs will supplement 6 million ITNs that were distributed over the last three years, Richard Ndyomugyenyi, the malaria control program officer, said.
The Autism Bill is back in Parliament for its third reading today. Having secured the Government"s support it is expected to pass to the House of Lords where it will be well on its way to becoming England"s first disability-specific law.
The National Infertility Awareness Campaign (NIAC) welcomed the document "Standardising Access Criteria to NHS Fertility Treatment"1 produced by Infertility Network UK (I N UK) and funded by the Department of Health.
Having partnered last year with an international team that surveyed the genomes of 12,000 individuals to find a genetic cause for gout, Johns Hopkins scientists now have shown that the malfunctioning gene they helped uncover can lead to high concentrations of blood urate that forms crystals in joint tissue, causing inflammation and pain - the hallmark of this disease.
The U.S. healthcare system is in critical need of basic change to enable more equitable, effective, efficient care. Experts in various fields of medicine, public health, and industry propose that telemedicine, or information technology enhanced healthcare, must be a core component of a viable healthcare reform strategy, a view they forcefully present in a white paper published online ahead of print in Telemedicine and e-Health, a peer-reviewed journal published by Mary Ann Liebert, Inc., the official journal of the American Telemedicine Association. The white paper is available free online
Scientists have unearthed striking evidence for a sudden ancient collapse in plant biodiversity. A trove of 200 million-year-old fossil leaves collected in East Greenland tells the story, carrying its message across time to us today.
In Los Angeles County, being disabled can cost a year"s income. That"s because the annual cost of in-home care services for seniors living alone is now $319 more than this group"s median income of $17,029.
Leaders of three national organizations representing nearly a third of a million physicians recently visited Capitol Hill offices to express their continued concern for America"s patients who do not have access to primary care physicians. The American Academy of Family Physicians (AAFP), the American College of Physicians (ACP) and the American Osteopathic Association (AOA) represent the majority of physicians who care for Medicare patients. The leaders noted that only 17 percent of U.S. medical school graduates in 2008 expressed a preference for a primary care specialty - an all-time low - at a time when demand for primary care is rapidly increasing.
Bioengineers at Duke University have developed a laboratory robot that can successfully locate tiny pieces of metal within flesh and guide a needle to its exact location -- all without the need for human assistance.
Throughout the animal kingdom brilliant colors or elaborate behavioral displays serve as "advertisements" for attracting mates. But, what do the ads promise, and is there truth in advertising? Researchers at Yale theorize that when males must provide care for the survival of their offspring, the males" signals will consistently be honest - and they may devote more of their energy to caring for their offspring than to being attractive.
A small study has shown that people tend to believe that bottled water is somehow healthier than water from the tap. However, the research, published in the open access journal BMC Public Health, also shows that people are unsure exactly what these benefits might be and that they are rarely the main reason for choosing bottled.
Accuray Incorporated (Nasdaq: ARAY), a global leader in the field of radiosurgery, announced that the Turkish Ministry of Health has purchased two CyberKnife(R) Robotic Radiosurgery Systems for installation in Ankara and Istanbul, Turkey.
The American Lung Association released its State of the Air: 2009 Report this month. The 10th annual report states that air pollution has significantly improved in some areas of the country, but major cities still have significant problems with pollutants.
A blueprint for a much-needed new generation of tuberculosis (TB) treatment has been developed by a team of scientists led at the University of Strathclyde in Glasgow.
A study of the award-winning Behavioral Pharmacy Management Program (BPM) shows the private-public Medicaid partnership program has helped improve patient care while saving eight states almost $95 million in behavioral health pharmaceutical costs. Lilly funds the program, which is designed and run by research firm Comprehensive NeuroScience, Inc. (CNS) at the sole direction and guidance of state Medicaid departments. The BPM, which has been executed in more than half of the states, has won a variety of national awards, including the Substance Abuse and Mental Health Services Administration Science and Service Award, URAC Silver Award for Best Practices in Consumer Empowerment and Protection, American Psychiatric Association Bronze Achievement Award and Disease Management Association of America Gold Award.
TranSenda International, LLC announced today that it is developing a new solution, Cortex, designed to improve an organization"s ability to manage a clinical trial"s performance. Based upon patent-pending ClinBUS® data interchange technology already in use in TranSenda"s Office-Smart solutions, Cortex will enable organizations to leverage the power of access to centralized operational data from all applications used across all clinical studies. For years the industry has struggled with an increasingly fragmented environment of disconnected clinical applications, sites and partners. TranSenda"s Cortex, with its proven ClinBUS technology, represents a breakthrough in managing and controlling studies within a common environment-independent of study data formats and clinical trial applications.
Seattle Genetics, Inc. (NASDAQ:SGEN), announced that it has initiated a phase II clinical trial of SGN-35 for patients with relapsed or refractory systemic anaplastic large cell lymphoma (ALCL). SGN-35 is an antibody-drug conjugate (ADC) that utilizes Seattle Genetics" proprietary technology to empower antibodies by linking them to potent cell-killing drugs.
Researchers have determined that individuals with mild to severe symptoms of lower urinary tract symptoms (LUTS) are more likely to suffer from metabolic syndrome (MetS), a collection of cardiovascular risk factors thought to be linked by insulin resistance). LUTS encompass voiding (incomplete emptying, weak stream, intermittency, straining) and storage (frequency, urgency, nocturia) difficulties.
A shocking four out of every ten people who suffer from a skin disease in the UK have been bullied as a result of their condition, a new snapshot survey reveals.
Accuray Incorporated (Nasdaq: ARAY), a global leader in the field of
School Nutrition Association president Dr. Katie Wilson, SNS announced new data today on the widespread availability of vegetarian school lunch options. Almost two thirds of school nutrition programs now offer a vegetarian school lunch on a consistent basis, up from 22% in 2003, according to the Association"s soon to be released 2009 School Nutrition Operations Report. The availability of vegetarian school lunches in a majority of districts is consistent with the overall trend in the past five years towards more nutritious school lunches emphasizing whole grains, fruits and vegetables, and low-fat dairy. The vegetarian choices also come in spite of federal school lunch reimbursements that have not kept pace with increased food and labor costs. Dr. Wilson presented the research findings at the National Conference on Childhood Obesity in Washington, DC today.
Several news organizations had explainers detailing the ongoing the health reform debate.
The winner of the Medical Journal of Australia"s Dr Ross Ingram Memorial Essay
Senate Passes Bill Including Flu Funds
Some Pacific Health Summit attendees said more action should have come from the tuberculosis-focused conference, which ended on Thursday in Seattle, Seattle Times" "Business of Giving" blog reports. Paula Akugizibwe, regional treatment advocacy coordinator for the AIDS and Rights Alliance for Southern Africa, said, "The gap between rhetoric and reality grows bigger and bigger," adding that she does not intend to attend anymore global health conferences, where people say the same things, then jet off to another conference and repeat the process.
Senate Democratic leaders on Thursday circulated talking points stating that Supreme Court nominee Sonia Sotomayor has a "mainstream record of judicial modesty," the AP/Miami Herald reports. The document includes a quote from Sotomayor expressing her belief in basing judicial decisions on the Constitution rather than on politics.Meanwhile, Senate Judiciary Committee Chair Patrick Leahy (D-Vt.) and ranking member Jeff Sessions (R-Ala.) also wrote to the president of LatinoJustice PRLDEF, formerly known as the Puerto Rican Legal Defense and Educational Fund, requesting the quick disclosure of documents Sotomayor has requested in relation to her work with the group (Hirschfeld Davis, AP/Miami Herald, 6/19). Sotomayor worked with the group from 1980 to 1992, assisting in a number of legal briefs and helping the group develop stances on public policy matters (Stanton, Roll Call, 6/18). According to the AP/Herald, interest groups and members of both political parties are "competing to define" Sotomayor ahead of her confirmation hearing, which is scheduled to begin July 13. Conservative groups have focused on labeling her an "activist" and singled out her involvement with PRLDEF as evidence of her support for abortion rights. The group sided with abortion-rights supporters in several major Supreme Court cases during Sotomayor"s time on its board (AP/Miami Herald, 6/19).
Neurocrine Biosciences, Inc. (Nasdaq: NBIX) announced additional positive safety and efficacy results from its Phase IIb clinical trial known as the Petal Study (603 study) using its proprietary, orally-active non-peptide Gonadotropin-Releasing Hormone (GnRH) receptor antagonist, elagolix, in patients with endometriosis. The Petal Study enrolled 252 patients, with a confirmed diagnosis of endometriosis, into three treatment groups; elagolix 150 mg once daily, elagolix 75 mg twice daily, or depo-subQ provera 104(TM) (DMPA) for six months of treatment followed by six months of no treatment. Database lock and unblinding of the full 48 week data set has provided more insight on the clinical benefits and safety profile of elagolix for the treatment of pain associated with endometriosis.
A federal recommendation that all pregnant women undergo testing for Group B strep bacteria has helped increase the number of screenings but also has produced a high level of false negatives, according to a study published Thursday in the New England Journal of Medicine, the AP/Newark Star-Ledger reports. Group B strep is a common bacteria in the intestines or lower genital tract. Although it poses no harm to most adults, during delivery it can be spread to infants, who can develop blood infections, pneumonia, meningitis, mental retardation, hearing and vision loss, or death. Problems occur in fewer than one in 3,000 births, but the Centers for Disease Control and Prevention in 2002 issued a recommendation that all pregnant women be tested because of the potential for serious complications. The study is the first research to examine the screening program. The researchers examined data on Group B strep cases in 10 states, finding that 250 infants out of nearly 7,700 were born with the infection. They compared the results with a similar study that was conducted before the CDC recommendations were in place, finding that the screening rate rose from 48% to 85% of pregnant women. The study also found that infant infections from Group B strep declined by 27%.Researchers predicted there would be between 44 and 86 false negatives in full-term infants, based on data from previous studies. However, their results showed about 60% of infected infants -- 116 cases -- were born to women who had tested negative for Group B strep. Researchers noted that the timing of a Group B test might play a role because the infection can come quickly, and tests could have been performed before the bacteria appeared. CDC recommends that pregnant women be screened between 35 and 37 weeks" gestation. CDC researcher Stephanie Schrag, who co-authored the study, said, "Maybe it was a true negative test, and the mother later became colonized" with the bacteria before delivery (Stobbe, AP/Newark Star-Ledger, 6/17).
Fresenius Medical Care, which operates the nation"s leading network of dialysis clinics, today endorsed the Performance Excellence and Accountability in Kidney Care (PEAK) campaign recently launched by Kidney Care Partners (KCP) - a coalition of patient advocates, dialysis professionals, care providers and manufacturers working together to improve quality of care for individuals with chronic kidney disease (CKD). The PEAK initiative is designed to significantly reduce the mortality rate for patients in their first year of dialysis.
Sports & Orthopaedic Specialists, a national leader in orthopedic care for women, in collaboration with Sister Kenny Sports and Physical Therapy, launched the renowned Prevent Injury and Enhance Performance (PEP) program to the local and regional market. PEP is an exercise and training program designed to significantly reduce the incidence of ACL injury and enhance performance as an added benefit.
The emergence of global health initiatives (GHIs), eg, The Global Fund and PEPFAR, has resulted in a striking expansion of key health interventions in recent years, from which millions have benefited. There is also evidence, however, that such initiatives can constrain the health systems of poor countries and that many opportunities to improve efficiency, equity, value for money and outcomes in global public health are still being missed. The health systems strengthening agenda needs more investment, and to be infused with the same sense of ambition and speed that has characterised GHIs. This is one of five key recommendations in a new multi-partner report published in a Health Policy paper in this week"s edition of The Lancet.
A new study analyzing the prevalence of sensory impairment among older U.S. workers found that hearing impairment prevalence was three times that of visual impairment, and that 38 percent of older workers reported experiencing either impairment.
Obesity is probably the most important factor in the development of insulin resistance, but science"s understanding of the chain of events is still spotty. Now, researchers at the Salk Institute for Biological Studies have filled in the gap and identified the missing link between the two. Their findings, to be published in the June 21, 2009 advance online edition of the journal Nature, explain how obesity sets the stage for diabetes and why thin people can become insulin-resistant.
Rapamycin, a drug given to transplant recipients to suppress their immune systems, has a paradoxical effect on cells responsible for immune memory, scientists at the Emory Vaccine Center have discovered.
Patients with an Implantable Cardioverter Defibrillator (ICD) have an ongoing risk of sudden incapacitation that might cause harm to others while driving a car. Driving restrictions are imposed making these recommendations an important guideline for patients.
"There are data in the literature suggesting an increased mortality in patients with chronic heart failure who are additionally suffering from cognitive decline", said Dr. Clotilde Balucani (Perugia, Italy) at the current meeting of the European Neurological Society (ENS). This major meeting in European neurology is gathering more than 2,900 experts from all over the world in Milan. Dr. Balucani and her colleagues are presenting a study funded by a research grant of the ENS.
Eurand N.V. (NASDAQ: EURX), a specialty pharmaceutical company that develops enhanced pharmaceutical and biopharmaceutical products based on its proprietary pharmaceutical technologies, announced that the U.S. Food and Drug Administration (FDA) has advised the Company that it has extended the June 2009 user fee goal date for the New Drug Application for ZENPEP™ (pancrelipase capsules) by three months.
Los Angeles, London, New Delhi, Singapore and Washington DC (19th June 2009) - Prison should be abolished in its current form, according to Joe Sim, Professor of Criminology at Liverpool John Moores University.
MRSA Survivors Network, the Chicago-based nonprofit and the official organization that launched World MRSA Day earlier this year is building momentum in the US, the UK and worldwide in its humanitarian grass-roots effort to raise awareness of the MRSA epidemic.
ORLANDO - Cisplatin/S-1 (CS) is non-inferior to cisplatin/5-fluorouracil (CF) for the treatment of advanced gastric/gastro-esophageal carcinoma and at the same time offers important safety improvements, according to phase III results released recently at a meeting of the American Society for Clinical Oncology (ASCO).
A concerned Rotherham nurse has forced manufacturers of an infant medicine feeder to withdraw its product following a safety scare. Nurse Karen Ray, a clinical procurement specialist at Rotherham Hospital, took her concerns to the Medicines and Healthcare products Regulatory Agency (MHRA) after a six-month-old baby was admitted to Rotherham Hospital following a liquid paracetamol overdose.
A new study in CMAJ (Canadian Medical Association Journal) shows that patients admitted to a hospital with coronary artery disease are twice as likely to quit smoking after receiving intensive smoking cessation support than those receiving minimal support.
Providence Tarzana Medical Center on Friday became the first. hospital in the nation to use the latest generation in imaging - the Ziehm Vision RFD - in this case to aid a surgeon in opening the clogged carotid artery of a patient who had suffered a small stroke.
Researchers at Children"s Hospital Boston have isolated a potent inhibitor of tumor metastasis made by tumor cells, one that could potentially be harnessed as a cancer treatment. Their findings were published in the online Early Edition of the Proceedings of the National Academy of Sciences during the week of June 22.
Loss of muscle strength, speed and dexterity is a common consequence of aging and a well-established risk factor for death, disability and dementia. Yet little is known about how and why motor decline occurs when it is not a symptom of disease.
Cancer the word resonates in people"s nightmares and strikes fear in the hearts of millions. Can there be a positive side amidst the panic, anxiety and hopeless feelings that often accompany the word? The answer is yes according to Dr. Patricia Mumby, associate professor Loyola University Chicago Stritch School of Medicine Psychiatry and Behavioral Neurosciences Department and director of Loyola Cardinal Bernadine Cancer Center Psychosocial Oncology Service.
ArcelorMittal and the American Red Cross are launching a new national partnership, Creating Safer Communities, designed to bring important safety training and res to people who live and work in communities where ArcelorMittal operates. ArcelorMittal, the world"s leading steel company, provided a grant of $152,500 to be distributed in multiple communities across the US. The program will provide health and safety education to more than 1,800 community members in addition to thousands of ArcelorMittal employees and their families.
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A coalition of union and liberal groups began running television ads designed to get "the attention of one particular television viewer: Sen. Kay Hagan," The Greensboro (N.C.) News & Record reports.
Australia"s leading nutrition organisation, the Dietitians Association of Australia (DAA), has
A severe lack of evidence is holding doctors back from providing the right treatment for workers suffering from Upper Limb Disorders, according to new research by the NHS Plus funded Occupational Health Clinical Effectiveness Unit (OHCEU) at the Royal College of Physicians. Upper Limb Disorders is an umbrella term for a number of common conditions of the shoulder, arm, wrist and hand, including carpal tunnel syndrome which is estimated to affect around 5% of UK adults
The Houston Department of Health and Human Services, along with several community health agencies, over the next three weeks is seeking to test 15,000 young adults for HIV as part of an effort to commemorate National HIV Testing Day on June 27, the Houston Chronicle reports. To encourage people to participate, those who take the test and receive their results and one hour of HIV education will get free tickets to a local hip-hop concert. A similar effort last year tested 2,700 young adults in two weeks, and roughly 7,500 were screened over seven weeks in 2007. Combined, the 2007 and 2008 efforts identified about 50 people with the virus, according to the Chronicle (George, Houston Chronicle, 6/21).
U.N. Secretary General Ban Ki-moon on Sunday at the Rotary International (RI) Annual Convention in Birmingham, U.K., said that governments worldwide should continue to work towards eradicating polio, BBC reports. Ban said polio is endemic in four countries - down from 125 countries in 1985 when RI launched its campaign, which has so far raised $250 million to eradicate the disease - BBC writes.
The muscle relaxer Botox has now been shown to positively affect the skin as well.
45th DIA Annual Meeting -- Booth # 1501 -- WorldCare Clinical, LLC (WCC), a leading imaging CRO for clinical trials in the pharmaceutical, biotechnology and medical device industries, announced that it is offering version 1.0 of the Metrics Champion Consortium (MCC) Imaging Performance Metrics to all sponsors" imaging trials beginning July 1, 2009, through its WorldPro™ technology solution.
Why the immune system of a pregnant woman does not attack her developing fetus is one of most remarkable features of pregnancy, and several underlying mechanisms have been described. However, Adrian Erlebacher and colleagues, at the New York University School of Medicine, New York, have now identified a new mechanism to explain why the mouse maternal immune system does not attack the fetuses.
Neovacs, a biotechnology company developing proprietary immunotherapeutics for autoimmune and chronic diseases, announced that subject to regulatory consent, it plans to initiate a Phase II study of its TNF-alpha Kinoid later this year in rheumatoid arthritis patients who have failed treatment with at least one TNF-alpha inhibitor. The decision to proceed with the trial was based on an initial review of encouraging data from the company"s Phase I/II study in Crohn"s disease.
Researchers have what they say is the first direct proof of a very old idea: that when we use a tool-even for just a few minutes-it changes the way our brain represents the size of our body. In other words, the tool becomes a part of what is known in psychology as our body schema, according to a report published in the June 23rd issue of Current Biology, a Cell Press publication.
Schizophrenia, a chronic and debilitating disorder marked in part by auditory hallucinations and paranoia, can strike in late adolescence or early adulthood at a time when people are ready to stand on their own two feet as fully independent adults.
Enzon Pharmaceuticals, Inc. (Nasdaq: ENZN) announced that it has opened its first Phase II trial for PEG-SN38 (EZN-2208), its novel proprietary cancer compound. The trial is open at multiple centers throughout the United States for patients diagnosed with metastatic colon cancer.
Regenerx Biopharmaceuticals, Inc. (NYSE Amex:RGN) (the "Company" or "RegeneRx") announced today that it is collaborating with the U.S. Army Medical Research Institute of Chemical Defense (USAMRICD) and Dr. Gabriel Sosne, Associate Professor of Ophthalmology at Wayne State University, to evaluate Tí˛4"s (RGN-259 eye drops) ability to prevent or reduce damage to the eye caused by exposure to chemical agents. The ability to prevent or reduce such damage is the focus of substantial efforts by both the military and homeland security. The project will consist of a series of research experiments over the next twelve months with Tí˛4, which is being commercially developed by RegeneRx and is in Phase II clinical trials.
Provectus Pharmaceuticals, Inc. (OTC BB: PVCT), a development-stage oncology and dermatology biopharmaceutical company, has begun a compassionate use program for PV-10 and has made the agent, which is in development as a therapeutic agent for a broad spectrum of cancers, available for select cancer patients.
ISPE, a global not-for-profit association of 25,000 pharmaceutical science and manufacturing professionals, announced that it is accepting proposals from pharmaceutical professionals for content that can be included in a variety of its educational res.
On the eve of an international meeting bringing together 200 African researchers to discuss progress on research for neglected tropical diseases (NTD), Merck & Co., Inc. and the not-for-profit Drugs for Neglected Diseases initiative (DNDi) announced a master agreement to support discovery and development of improved treatments for NTDs.
Among older adults, less frequent participation in social activity is associated with a more rapid rate of motor function decline, according to a report in the June 22 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
A new study at the University of Leicester is using advanced single molecule methods to explore processes that lie at the very core of DNA variation in humans.
We humans prefer to be addressed in our right ear and are more likely to perform a task when we receive the request in our right ear rather than our left. In a series of three studies, looking at ear preference in communication between humans, Dr. Luca Tommasi and Daniele Marzoli from the University "Gabriele d"Annunzio" in Chieti, Italy, show that a natural side bias, depending on hemispheric asymmetry in the brain, manifests itself in everyday human behavior. Their findings were just published online in Springer"s journal Naturwissenschaften.
Melatonin can slow down the effects of aging. A team at laboratoire Arago in Banyuls sur Mer (CNRS / Universitç© Pierre et Marie Curie) has found that a treatment based on melatonin can delay the first signs of aging in a small mammal. These results appeared in the journal PLoS ONE on 15 June 2009.
High cholesterol levels are considered to be a risk factor not only for cardiovascular disease including stroke, but also for the development of Alzheimer"s disease. Therefore, many cholesterol lowering drugs, including statins, have been developed in recent years. In addition to the cholesterol reducing effect of statins Amalia Dolga, PhD, of the University of Groningen, The Netherlands, and her co-investigators have demonstrated that statins can protect nerve cells against damage which we know to occur in the brain of Alzheimer"s disease patients. The results are published in the June issue of the Journal of Alzheimer"s Disease.
CorNova Inc. announced that it has received CE mark approval for its Valecor Platinum Coronary Stent System.
The American Cancer Society and the National Palliative Care Research Center (NPCRC) are awarding $1.5 million in research grants to researchers at eleven institutions for studies aimed at reducing suffering for seriously ill patients and their family caregivers. The studies will be conducted over the next two years. The NPCRC, in collaboration with the American Cancer Society, has directed over $5 million towards supporting 38 palliative care research projects since starting this initiative three years ago.
A report in Cancer Research, a journal of the American Association for Cancer Research, highlights a new biomarker that may be useful in identifying patients with recurrent glioblastoma, or brain tumors, who would respond better to anti-vascular endothelial growth factor therapy, specifically cediranib.
"House Democrats are pushing forward with a partisan health care bill even as a key Senate Democrat labors to achieve an elusive bipartisan compromise on President Barack Obama"s top legislative priority," The Associated Press reports. "The draft legislation, written without Republican help, would require all Americans to purchase health insurance and would put new requirements on employers, too." The House bill was unveiled last week and "is to be weighed in hearings beginning Tuesday."
The White House formally announced the drug manufacturers" plan to lower Medicare drug prices Monday. While details still remain unclear, it appears drug companies may benefit from the deal.
Tonia Odom, a 35-year-old patient with rheumatoid arthritis, a sick father and a young son, each of whom has multiple health problems, has found some relief to the problems of managing her families" array of illnesses in at a Duke University clinic that"s a model of the "medical home" approach to medicine, the New York Times reports. "As President Obama and Congress try to create a national system that provides better care for more people at lower cost, you are likely to hear a lot more about this idea. The term, coined by the American Academy of Pediatrics in 1967, is admittedly confusing. It does not mean a return to house calls. Nor need it apply only to people with complex health problems like those of the Odom family."
The number of polio cases in Nigeria has gone down from 799 in 2008 to 353 this year, according to the country"s National Primary Health Care Development Agency (NPHCDA), Africa Science News Service reports. The number of children who have never had a polio vaccine has been reduced from 16 percent in 2008 to 8 percent in 2009, NPHCDA Executive Director Mohammed Ali Pate said.
Two years ago more than one in four newborns screened for metabolic and other inherited
Scientists at the University of Alberta have found that there are significant differences in the way our brains function depending on whether we"re early risers or night owls.
New research from Vanderbilt University indicates the way our brain handles how we move through space - including being able to imagine literally stepping into someone else"s shoes - may be related to how and why we experience empathy toward others.
Allosteric modulation company Addex Pharmaceuticals (SWISS: ADXN) announced today that its partner Ortho-McNeil- Janssen Pharmaceuticals Inc. (OMP) has started Phase I testing of ADX71149, a metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulator (PAM). This product, which has potential to treat schizophrenia, anxiety, depression and other CNS disorders, is the first PAM of any mGluR subtype to enter clinical trials. Targeting mGluR2 with a PAM is a novel approach that may offer advantages over classical drug approaches. In reaching this milestone, Addex received a EUR 1 million payment from OMP and remains eligible for additional development milestones and royalties.
Dr. Janet D. Latner, an Associate Professor of Psychology at the University of Hawai"i at Manoa, has co-authored an article in the July 2009 edition of the Journal of Sex & Marital Therapy on "Weight Stigma in Existing Relationships."
The global economic crisis has had a devastating impact on the world"s hungry. In the past year, approximately 100 million people have been added to the ranks of the roughly 1 billion people worldwide considered by the United Nations Food and Agricultural Organization to be undernourished, according to its report issued June 19, 2009.
Approximately 5 million adults age 19 to 23 in the United States had no health insurance in 2006 for the entire year and 30 percent of them said they didn"t think it was worth the cost, according to the latest News and Numbers from the Agency for Healthcare Research and Quality.
Conatus Pharmaceuticals Inc. announced the initiation of a second Phase 2 clinical trial with a novel drug candidate for the treatment of liver disease associated with Hepatitis C Virus (HCV) infection. The trial will enroll patients for whom treatment with approved standard of care treatments is not currently advised. Results from an earlier clinical trial in HCV patients who failed standard of care treatment are expected to be reported later this year.
A UCLA study has discovered that chronic exposure during pregnancy to miniscule levels of carbon monoxide damages the cells of the fetal brain, resulting in permanent impairment. The journal BMC (BioMed Central) Neuroscience published the findings June 22 in its online edition.
Iraqi health authorities confirmed yesterday that six people recently returned from the US have tested positive for H1N1 epidemic or swine flu,
Resolvyx Pharmaceuticals, Inc., the leading resolvin therapeutics company, today announced that it has initiated the first human clinical trial evaluating an oral resolvin therapeutic, RX-10001, in a Phase I clinical trial in healthy volunteers. RX-10001 is a synthetic form of RvE1, a naturally occurring resolvin, which in animal studies has been shown to activate the body"s own off-switch mechanisms for inflammation and to promote healing for normal tissue function. In preclinical testing, RX-10001 and analogs have shown high potency across a range of inflammatory disease models, including asthma, colitis, rheumatoid arthritis, and atherosclerosis.
Scientists at The Institute of Cancer Research (ICR) and The Royal Marsden Hospital, working with pharmaceutical company AstraZeneca, have completed a Phase I clinical trial demonstrating the great promise of a completely new type of cancer treatment. The results are announced today in The New England Journal of Medicine.
The British Society of Gastroenterology (BSG) is hosting a meeting at Number 11, Downing Street today to raise awareness of how more than half of Britain"s hospitals are providing patients with inadequate services. A UK-wide audit shows that 60% of acute upper gastrointestinal bleeding episodes occurred out of "normal" working hours yet 45% of hospitals do not provide out of hours endoscopy.
Hospitals could sign on to an agreement with Senate health reform leader Max Baucus, D-Mont., and the White House to help save up to $200 billion as part of the overhaul plan, lobbyist and health industry s tell Roll Call. The possible deal would come on the heels of an agreement between the drug industry lobbying group, Pharmaceutical Research and Manufacturers of America and senior Democrats to save $80 billion over 10 years by expanding the Medicare drug program. The American Hospital Association, the Federation of American Hospitals and the Catholic Health Association are all said to be in talks about the potential bargain.
The method of building a rabbit rectal VX2 carcinoma model by injecting the cell suspension of VX2 cells into the wall of the rectum guided by X-ray fluoroscopy is feasible. The advantages of the model are ease of establishment, short growth period, and high stability. The rectal VX2 carcinoma established in this rabbit model is similar to human rectal carcinoma in aspects of pathological representation, tumor development, and metastasis. It offers an ideal major animal model for the study of rectal carcinoma, and especially profits the study of the staging of rectal carcinoma in imaging.
A Christian-theater troupe and other area religious leaders are participating in HIV testing efforts targeting the black community in Greater Cincinnati and Northern Kentucky as part of National HIV Testing Day, the Cincinnati Enquirer reports. According to the Enquirer, local public health officials have long struggled to encourage blacks and other groups to get tested for HIV. Increased awareness efforts by black religious leaders and national initiatives - such as the "Test One Million" campaign organized by the Black AIDS Institute in Los Angeles - have recently focused attention on HIV/AIDS in the black community, Mamie Harris, founder and executive director of IV-Charis, the lead agency in Cincinnati for the "Test One Million" campaign, said (O"Farrell, Cincinnati Enquirer, 6/23).
The journal Lancet Infectious Diseases examines whether President Obama is fulfilling his campaign promises to tackle HIV/AIDS abroad and at home. Although Obama has surrounded himself "[w]ith lauded experts ň€¦ concerns have been raised by activists that investment plans are not matching up to the rhetoric," Lancet writes.
The Rheumatology Futures Project and the Department of Health have launched a new 18-week commissioning pathway for inflammatory arthritis (IA).
The Louisiana House on Tuesday voted 88-12 in favor of a bill (H.B. 517) that would expand the ability of health care workers to refuse to participate in certain services based on moral or religious beliefs, the AP/USA Today reports. The bill now goes to Gov. Bobby Jindal (R), who is expected to sign it.The bill would shield health workers from civil and criminal penalties, job loss or demotion if they refuse to provide certain services based on moral objections or religious beliefs. According to the AP/USA Today, these services could include "abortion, certain types of emergency contraception, human embryonic stem cell research, human embryo cloning, euthanasia or physician-assisted suicide." Opposition to the bill lessened with the addition of certain amendments, including a provision that would require health providers to notify their employers in writing of any procedures or services to which they would object. Another amendment would require facilities to ensure that adequate staff is available to provide services and information that would be refused (Deslatte, AP/USA Today, 6/24).The conservative Louisiana Family Forum advocated for the bill. The Planned Parenthood Federation of America and the American Civil Liberties Union opposed it, arguing that patients would be denied access to services and information (Barrow, New Orleans Times-Picayune, 6/23).
The Family Building Act of 2009 (H.R. 697, S. 1258) "takes an important first step toward improving the way insurers view infertility," but it is "not a silver bullet for improving the way [in vitro fertilization] treatments are conducted and covered," John Zhang, founder and director of the New Hope Fertility Center in New York City, writes in an opinion piece in The Hill. The bill, introduced by Rep. Anthony Weiner (D-N.Y.) in the House and Sen. Kirsten Gillibrand (D-N.Y.) in the Senate, would require health insurance companies that cover obstetrical services to cover non-experimental treatment of infertility, including IVF.Zhang writes that one of the "most significant issues is that multiple-embryo transfers have become common practice," which increase the risk for premature delivery, contribute to infant mortality rates and add to costs. According to Zhang, the lack of federal guidelines, "coupled with failure by the insurance industry to cover IVF treatment in the U.S., has encouraged patients to insist on multiple embryo transfer to get the most out of the enormous out-of-pocket fees they incur per cycle." In addition, "because doctors are rewarded for better success rates, the emphasis moves from quality to quantity so that clinics may boost their success rates despite potentially dangerous and expensive health complications," Zhang writes.Zhang continues that if IVF "were more accessible and reimbursed by health insurers, and if embryo transfers were regulated, there would be consequences for clinics and physicians who practice irresponsibly," and it "would be nearly impossible for IVF to lead to high-order multiples with their attendant risks." Although the Family Building Act "addresses this problem from an insurance perspective, it does not incorporate all the critical pieces that would encourage more responsible IVF practices among patients and physicians," according to Zhang.Zhang suggests that lawmakers "set age limitations on insurance coverage to encourage responsible spending" and that regulators "revise the outdated IVF reporting system and start providing incentives that encourage responsible medical practices." He concludes that it is "crucial that legislators and doctors work together to create a regulated and safe environment for IVF patients that upholds the integrity of our country"s medical profession" (Zhang, The Hill, 6/22).
Transferring heart attack patients to specialized hospitals to undergo angioplasty within six hours after receiving clot-busting drugs reduces the risk of life-threatening complications including repeat heart attacks, according to a new study from St. Michael"s Hospital and Southlake Regional Hospital.
A new study by a University of Arizona professor shows employee involvement programs that executives adopt to increase efficiency also end up improving their record on diversity.
The latest figures from the Confidential Enquiry into Maternal and Child Health (CEMACH) Perinatal Mortality Surveillance Report 2007 show improvements in the stillbirth and neonatal death rates in the UK.
Investigators at Children"s Hospital Oakland Research Institute, Oakland, California found a way to obtain large numbers of hematopoietic stem cell from human term placenta. The results, which appear in the July 2009 issue of Experimental Biology and Medicine, describe detailed report on quantification, characterization, engraftment capacity, and most importantly, practical way to obtain hematopoietic stem cells from placenta in numbers that are several-fold higher than could be obtained from cord blood.
Researchers led by Drs. James F. George and Anupam Agarwal at the University of Alabama at Birmingham have found that carbon monoxide (CO) can protect against arterial clotting. They report their data in the July 2009 issue of the American Journal of Pathology.
Joel B. Nelson, M.D., chairman of the University of Pittsburgh Medical Center"s (UPMC) Department of Urology, performed his 2,000th radical prostatectomy at UPMC Shadyside, a milestone achieved by only a handful of surgeons worldwide. Radical prostatectomy, or removal of the entire prostate gland, is the most common treatment for patients with localized prostate cancer. Studies show that recovery from prostate cancer is significantly associated with a surgeon"s lifetime experience performing this operation.
The first clinical trial funded by the new Efficacy and Mechanism Evaluation (EME) programme will investigate whether a simple procedure to activate one of the body"s natural defence mechanisms improves the function of kidneys after transplantation. This research is funded by the Medical Research Council and managed by the National Institute for Health Research.
ThromboGenics NV (Euronext Brussels: THR), a biotechnology company focused on the discovery and development of innovative treatments for eye disease, vascular disease and cancer, announces that its lead product microplasmin, which is in Phase III trials for the treatment of vitreomacular adhesion, is progressing according to schedule. All protocol-specified, interim masked analyses by the independent Data Monitoring Committee (DMC) have been completed. Recruitment is on track and the DMC, having found no safety concerns, has unanimously recommended proceeding without protocol modification.
More pieces in the complex autism inheritance puzzle are emerging in the latest study from a research team including geneticists from The Children"s Hospital of Philadelphia, the University of Pennsylvania School of Medicine and several collaborating institutions. This study identified 27 different genetic regions where rare copy number variations missing or extra copies of DNA segments were found in the genes of children with autism spectrum disorders (ASDs), but not in the healthy controls. The complex combination of multiple genetic duplications and deletions is thought to interfere with gene function, which can disrupt the production of proteins necessary for normal neurological development.
Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specific microRNAs (non-coding RNAs that interfere with gene expression) reduce HIV replication and infectivity in human T-cells. In particular, miR29 plays a key role in controlling the HIV life cycle. The study suggests that HIV may have co-opted this cellular defense mechanism to help the virus hide from the immune system and antiviral drugs. The research was published today in the journal Molecular Cell.
Summaries of efforts by groups outside the political arena to be included in the debate over health care reform legislation appear below.
If a lump is found in the breast of an adolescent girl, she often will undergo an excisional biopsy.