Popular Articles

A Compound Found In The Sea Provides Promising New Treatment For Neuropathic Pain
A paper just published in the British Journal of Pharmacology reports that a compound originally isolated from a soft coral (Capnella imbricate) could lead scientists to develop a new variety of treatments for neuropathic pain. This composite is collected at Green Island off Taiwan and could be a new option for treatment. Neuropathic pain is chronic and occasionally follows damage to the nervous system. Presently this type of pain is very poorly controlled by the usual analgesics: aspirin like drugs (NSAIDS) or even opioids like morphine. New treatments are urgently required.

Research Uncovers Clues To Virus-Cancer Link
In a series of recently-published articles, a research team from the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center has uncovered clues to the development of cancers in AIDS patients.
News of the day
ChIP-Seq, Drosophila Targeted Mutagenesis Featured In Cold Spring Harbor Protocols
High-throughput whole-genome analysis is becoming a standard laboratory approach for investigating cellular processes. Next-generation sequencing is replacing microarrays as the technique of choice for genome-scale analysis, because it offers advantages in both sensitivity and scale. The June issue of Cold Spring Harbor Protocols features "Native Chromatin Preparation and Illumina/Solexa Library Construction" from Keji Zhao and colleagues at the National Heart, Lung and Blood Institute. The article describes sample preparation for sequencing of chromatin-immunoprecipitated DNA (ChIP-Seq) to analyze histone modification patterns using native chromatin and the Solexa/Illumina Genome Analyzer. Step-by-step instructions are given for purification of human CD4+ T cells from lymphocytes and chromatin fragmentation using micrococcal nuclease (MNase) digestion, followed by chromatin immunoprecipitation (ChIP) and construction of a library for sequencing. The article is freely available on the website for Cold Spring Harbor Protocols (http://cshprotocols.cshlp.org/cgi/content/full/2009/6/pdb.prot5237).
Oncology

With Shrinking Budgets, States Cutting Health Services

As state revenues continue their downturn due to the recession, 16 states are trying to find ways to deal with increased health care costs, The New York Times reports: "The carnage in state budgets is getting worse, a report said Thursday, with places like Arizona being hurt by falling revenue on multiple fronts, like personal income and sales taxes. Other states are having mixed experiences, with some tax categories stable, or even rising, even as others fall off the map." The Times covered a National Conference of State Legislatures report on state financial conditions, and how they compared to the last fiscal year. "Thirty-one states said estimates about personal income taxes had been overly optimistic, and 25 said that all three major tax categories - sales taxes, personal income taxes and corporate taxes - were not keeping up with projections." The greatest decrease in personal income tax collections occurred in New York, where revenues fell by 49 percent compared to last year. The largest drop in sales taxes occurred in Washington, where revenues fell by 19 percent. The biggest decline in corporate tax revenues--44%-occurred in Oregon. "A report issued by the group in April said that spending increases related to the recession, from more people seeking state services, were compounding the impact of a decline in tax revenue. Sixteen states were facing higher-than-anticipated costs for health care ..." (Johnson, 6/4). In other state budget news: The Associated Press reports that Wyoming is cutting $43 million from its Department of Health budget, mostly from Medicaid: "The governor also said he is recommending capping enrollment in the SCHIP Kid Care program at 5,900 participants." The program now has just over 5,500 enrolled (Neary, 6/4). *Budget cuts in California are threatening Alzheimer"s patients, The Los Angeles Times reports: "Among the cuts being discussed to close a projected $24-billion state deficit are proposals to dismantle many of the programs that help California"s poorest cope with Alzheimer"s" (Zavis, 6/5). *Delaware joins parts of Washington state as places where Walgreen won"t fill Medicaid prescriptions because of reduced payment rates for brand name drugs. State officials maintain that the payment rate drop would help the state offset part of the $800 million budget shortfall, Reuters reports (Wohl, 6/4). *The Ohio Senate has rejected Gov. Ted Strickland"s proposals "that would have reduced the rates insurers can charge people with pre-existing conditions from an average of $800 a month to less than $400, according to the state Insurance Department." The agency said the proposals could have expanded private health insurance to 110,000 state residents, reformed open-enrollment programs and offered state continuation of coverage to employees of small businesses who lose their jobs, Business Insurance reports (Casale, 6/4). The News & Observer reported that potentially deep budget cuts worry North Carolina health officials because they could occur just as the state needs more res to prepare for swine flu. Dr. Jeffrey Engel, the state"s public health chief, warned Thursday about budget cuts up for consideration next week saying, "The perfect storm would be mass budget cuts and a widespread pandemic" (Martin, 6/5). This information was reprinted from kaiserhealthnews.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Health Policy Report, search the archives and sign up for email delivery at kaiserhealthnews.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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