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Pandemic Could Overwhelm Critical Care Beds In England, Especially Children's Units
Experts in intensive care and anaesthesia have predicted that the current swine flu pandemic could overwhelm critical care beds and ventilators in England, with hospitals on the South East Coast, and in the South West, East of England and East Midlands, being worst hit.

Bypass Or Angioplasty No Better Than Drug Therapy In Reducing Deaths Among Patients With Type 2 Diabetes And Heart Disease
There is no difference in mortality among patients with type 2 diabetes and stable heart disease who received prompt bypass surgery or angioplasty compared to drug therapy alone, according to a landmark study focused exclusively on patients with both conditions. The study, which was led by investigators at the University of Pittsburgh Graduate School of Public Health, published in the June 11 issue of the New England Journal of Medicine and presented at the American Diabetes Association 69th Scientific Sessions, also found that while prompt bypass in patients with more severe heart disease did not lower mortality, it lowered their risk of subsequent major cardiac events.
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BioSante Pharmaceuticals Comments On Benefits Of Testosterone Use In HIV-Infected Women
BioSante Pharmaceuticals, Inc. (NASDAQ: BPAX), which is developing a testosterone gel (LibiGel®) for the treatment of hypoactive sexual desire disorder (HSDD) in menopausal women, today commented on a paper published in the May 15, 2009 issue of AIDS, the Journal of the International AIDS Society, on the effect of testosterone in women infected with HIV. The peer-reviewed journal reported results of a randomized, placebo-controlled trial of testosterone in HIV-infected women indicating that long-term testosterone administration was well tolerated in HIV-infected women and resulted in significant improvement in body composition, bone mineral density (BMD), and quality of life indices.
Endocrinology

The Ultimate Brow Lift: HDAC8 In The Epigenetic Control Of Skull Morhpgenesis

In the July 15th cover story of G and D, a research team led by Dr. Eric Olson at the UT Southwestern Medical Center at Dallas reports that the class I histone deacetylase 8 (HDAC8) enzyme regulates gene expression in the developing vertebrate skull. HDAC8 overexpression is associated with a poor prognosis in human neuroblastoma patients. "As there are many different isoforms of histone deacetylases, it is crucial to understand the specific function of each -- with the putative goal of targeting a specific subset for a specific disease process," explains Dr. Mike Haberland, lead author on the study. Dr. Olson"s team explored the role of HDAC8 in verterbrate skull morphogenesis, using a strain of knockout mice specifically lacking HDAC8 in cranial neural crest cells. Neural crest cells (NCCs) are a specialized group of embryonic cells that - among other things - have evolved to generate the unsegmented vertebrate head, which has allowed vertebrates to transform from a passive, filter feeding animal into an active predator with paired eyes, an enlarged brain and protective skull, and ultimately, teeth and jaws. The researchers found that HDAC8 deletion causes a deficiency of cranial NCCs, resulting in skull dysmorphism and instability, and perinatal death due to brain trauma. Microarray profiling revealed that HDAC8 represses multiple homeobox transcription factors that are active in the cranial NCC population, and function to pattern the frontal skull. Thus, HDAC8 has a crucial role in the epigenetic control of vertebrate skull development. Heather Cosel-Pieper Cold Spring Harbor Laboratory


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