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New Genetic Immune Disorder In Children Discovered By Scientists
Your immune system plays an important function in your health - it protects you against viruses, bacteria, and other toxins that can cause disease. In autoinflammatory diseases, however, the immune system goes awry, causing unprovoked and dangerous inflammation. Now, researchers from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health, and other institutions have discovered a new autoinflammatory syndrome, a rare genetic condition that affects children around the time of birth. The findings appear in the current issue of the New England Journal of Medicine.

Addex Partner Starts First-Ever Clinical Trial Of An MGluR Positive Allosteric Modulator
Allosteric modulation company Addex Pharmaceuticals (SWISS: ADXN) announced today that its partner Ortho-McNeil- Janssen Pharmaceuticals Inc. (OMP) has started Phase I testing of ADX71149, a metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulator (PAM). This product, which has potential to treat schizophrenia, anxiety, depression and other CNS disorders, is the first PAM of any mGluR subtype to enter clinical trials. Targeting mGluR2 with a PAM is a novel approach that may offer advantages over classical drug approaches. In reaching this milestone, Addex received a EUR 1 million payment from OMP and remains eligible for additional development milestones and royalties.
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BPA, Chemical Used To Make Plastics, Found To Leach From Polycarbonate Drinking Bottles Into Humans Exposure To BPA May Have Harmful Health Effects
A new study from Harvard School of Public Health (HSPH) researchers found that participants who drank for a week from polycarbonate bottles, the popular, hard-plastic drinking bottles and baby bottles, showed a two-thirds increase in their urine of the chemical bisphenol A (BPA). Exposure to BPA, used in the manufacture of polycarbonate and other plastics, has been shown to interfere with reproductive development in animals and has been linked with cardiovascular disease and diabetes in humans. The study is the first to show that drinking from polycarbonate bottles increased the level of urinary BPA, and thus suggests that drinking containers made with BPA release the chemical into the liquid that people drink in sufficient amounts to increase the level of BPA excreted in human urine.
Sexual Health

Spread Of Swine Flu Detracting From Real Issue, Says UK Charity

Millions of children will continue to die of preventable causes unless health and development ministers get their priorities straight next week in Geneva, says leading aid agency World Vision. Days before UK Government Ministers fly to the World Health Assembly, World Vision is urging them to support a vital resolution on primary health care, and place it at the centre of the development agenda. World Vision CEO Justin Byworth has written to Health Secretary Alan Johnson, and to the Department for International Development, to stress that swine flu and the global recession "emphasise the need for national and global leadership to protect health, especially in developing countries where these threats may be less visible but are often more acute". Despite 9.2 million children dying each year from avoidable causes such as diarrhoea, pneumonia and measles, many countries are still not delivering on their global health promises. Many governments are also failing to prioritise the most essential, life-saving community-based health systems, provisions and education. "This is arguably the biggest child rights violation of our generation," said World Vision UK Health Adviser, Kate Eardley. "There"s a real risk that the current media and political focus on swine flu will divert energy and res away from the ongoing child health emergency in the world"s poorest countries. While the World Health Assembly needs to respond to current events, it must not take its eye off the ball in terms of reducing child deaths by the UN target of 2015. With six years to go, we are way off track on achieving this promise," Eardley said. "In order to help reduce child mortality by 60 per cent, and save more than five million children, primary health care must remain central to the Assembly"s agenda. "High levels of child mortality reflect a lack of political will, misguided health policy and spending, and inadequate investment in maternal, neonatal and child health at the community level. "Business as usual at the World Health Assembly will not save the millions of lives it should. A renewed focus and targeted investment in primary health care, particularly at family and community level, is urgently needed." World Vision is calling on the UK Government to clearly reaffirm the commitments it made to reduce child and maternal mortality by 2015, at the World Health Assembly. "They can show us how serious they are, by prioritising primary health care," said Eardley. Kate Eardley, World Vision UK Health Adviser, will be at the World Health Assembly in Geneva. Contact Tennille Bergin on + (44) 7876 503 978 for more information. World Vision briefing "Putting Children at the Centre of Health Care" is also available. World Health Assembly


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