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Mabthera(R) (Rituximab) Available On NHS For UK's Most Common Leukaemia
The National Institute for Health and Clinical Excellence (NICE) today issued its recommendation for the use of MabThera® (rituximab) in the UK"s most common form of leukaemia, chronic lymphocytic leukaemia (CLL).1,2,3 NICE"s final guidance recommends rituximab in combination with fludarabine and cyclophosphamide (FC) chemotherapy as an option for previously untreated patients with CLL.4 The addition of rituximab to FC chemotherapy has been proven to halt progression of the disease by 10.5 months longer than chemotherapy alone, and more than doubles the number of CLL patients achieving complete remission, compared to chemotherapy.5,6 More than 20,000 people in the UK are living with CLL and there are an estimated 3,700 new cases every year.7,8 Professor John Gribben, Consultant Haematologist and Medical Oncologist, Barts and The London NHS Trust, commented:
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Landmark Five-Year African Study Indicates That HIV Therapy May Be Given Safely In Re-Limited Settings Without Routine Laboratory Monitoring
Gilead Sciences, Inc. (Nasdaq:GILD) highlighted results from a study known as DART (Development of Anti-Retroviral Treatment in Africa), which evaluated the need for routine laboratory monitoring in adults taking antiretroviral therapy in Africa. The DART trial was an open-label, randomized study comparing clinical and laboratory monitoring to clinical monitoring alone for efficacy and toxicity. In this study, 74 percent of patients were on a treatment regimen containing Viread® (tenofovir disoproxil fumarate). At baseline, more than 50 percent of patients had reduced renal function. The results indicated that Viread was well tolerated and that the incidence of renal adverse events was low. DART researchers concluded that renal function test results were similar in both arms of the trial for up to five years, suggesting that routine monitoring of Viread may not be necessary in re-limited settings when using the product as part of a first-line HIV treatment regimen. The results of the study were presented today at the 5th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2009) in Cape Town, South Africa.
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Critics Escalate Attacks On Health Care Overhaul
Tensions are showing as health reform continues to be center stage on the President"s and Congress" domestic policy agenda. The Associated Press reports that "President Barack Obama has learned the lessons of Bill Clinton"s failed bid to overhaul the nation"s health care system. Too well, in fact, say fellow Democrats angry over [Obama"s] refusal to intervene while a conservative proposal advances in the Senate," feel Obama has "over-learned the lessons of 1993 and is bending over too far to attract GOP support in the Senate." Obama supports a public option for health insurance, but "wants to avoid issuing nonnegotiable demands early in the legislative process," say White House aides. "Insurance companies oppose the public option proposal. Their cause was hurt this week when congressional investigators said two-thirds of the U.S. health insurance industry used a faulty database that overcharged patients for seeing doctors outside their insurance network, costing Americans billions of dollars in inflated medical bills" (Babington, 6/26).
Oncology

School Burnout Suffered By One In Five Girls In Upper Secondary School

The transition from basic education to upper secondary school is a challenge for many young people. According to a study of school burnout at different stages of school and higher education, upper secondary school is a particularly challenging stage for many young people. Success-oriented female upper secondary school pupils are at the greatest risk: up to 20 cent of them suffer from school burnout. Burnout is a phenomenon to be taken seriously, as it can lead to depression. "These girls are high achievers but they also develop burnout. They tend to develop feelings of inadequacy, in particular, in upper secondary school. By contrast, boys who enter upper secondary school tend to develop more of a cynical, negative stance towards school," says Professor Katariina Salmela-Aro of the University of Jyvç¤skylç¤, who is in charge of the research. The study was carried out at the Academy of Finland"s Centre of Excellence in Learning and Motivation Research, and comprised 1,800 young people. The study focused particularly on students" trajectories to well-being or problems during transitional stages in their education. "Transitions from one stage of education to the next have an impact on the well-being of young people and they need support during these life stages. A healthy level of self-esteem is a protective factor," Salmela-Aro says. According to Salmela-Aro, school burnout in upper secondary school tends to complicate the transition to further studies, while an enthusiasm for school tends to predict a successful transition to the next education level. "This research finding has considerable importance for the efforts to encourage young people to make a faster transition into further studies and working life." Medical students are the keenest For the first time in Finland, research was also conducted on burnout and academic engagement among students in higher education. The material was provided by the Finnish Student Health Service (FSHS) and comprised 5,200 students. Results show that one in ten students in higher education suffers from burnout and one in three is at risk. However, the good news is that one in four students in higher education feel enthusiasm for their studies. Medical students were most likely to be enthusiastic about their studies and least likely to suffer from burnout. "Students" engagement for their studies declines over time, which raises the question of what happens to the highly motivated students who enter higher education. A sense of optimism during university studies along with high self-esteem tend to predict job engagement ten years later on, while an avoidance strategy tends to predict work-related burnout," Katariina Salmela-Aro says. School burnout is a chronic school-related stress syndrome which manifests as exhaustion, cynicism about school and feelings of inadequacy. Engagement about school is characterised by energy, dedication and an ability to become absorbed in the work. In basic education, school burnout is caused by a negative atmosphere in school, usually in the form of a stressful and restless working environment. Support from the adult staff of the school, especially the school healthcare services, helps reduce school burnout. Teachers who have a positive attitude and an ability to motivate students are extremely helpful for upper secondary school students. The more encouragement the students got from their teachers, the less likely they were to experience school burnout. Riitta Tirronen Academy of Finland


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