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DNA Binding Compound That Kills Bacteria In 2 Minutes Could Lead To New Antibiotics
A synthetic DNA binding compound has proved surprisingly effective at binding to the DNA of bacteria and killing all the bacteria it touched within two minutes. The DNA binding properties of the compound were first discovered in the Department of Chemistry at the University of Warwick by Professor Mike Hannon and Professor Alison Rodger (Professor Mike Hannon is now at the University of Birmingham). However the strength of its antibiotic powers have now made it a compound of high interest for University of Warwick researchers working on the development of novel antibiotics.

HCL Welcomes Government Proposals For More Flexible NHS, UK
HCL plc, the UK"s largest health and social care recruitment agency, said the Government"s proposals to reform the NHS by devolving power to frontline professionals and patients will mean a greater need for flexible staffing and more collaboration between the public and private sectors.
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Informa Healthcare To Launch Beta Site
Informa Healthcare - one of the world"s leading medical and scientific publishers - has announced that the new interactive http://www.informahealthcare.com beta site will go live in July.
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New Support For A Controversial Mechanism Underlying An Irregular Heart Beat

The most common form of human heart beat irregularity (atrial fibrillation) can be fatal if left untreated. It has been suggested that it is caused, in part, by calcium leaking from a cellular store in heart cells, potentially through the RyR2 channel, although this mechanism remains controversial. However, a team of researchers at Baylor College of Medicine, Houston, and Dresden University of Technology, Germany, has provided support for this hypothesis by showing that the protein CaMKII can enhance RyR2-mediated calcium leak, promoting atrial fibrillation in mice. The team, led by Xander Wehrens and Dobromir Dobrev, studied mice engineered to express a mutant form of RyR2 associated with calcium leak. Although these mice did not spontaneously develop atrial fibrillation, they were more likely to develop atrial fibrillation than normal mice if their heart rate was forced up. This was related to the functional interaction of CaMKII with RyR2, and blocking CaMKII function in these mice prevented them from developing atrial fibrillation when their heart rate was forced up. As a functional link between CaMKII and RyR2 was observed in heart biopsies from patients with chronic atrial fibrillation, the authors suggest that enhanced CaMKII function might increase calcium leakage via RyR2 and initiate clinical atrial fibrillation. TITLE: Calmodulin kinase II - mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice AUTHORS: Xander H.T. Wehrens Baylor College of Medicine, Houston, Texas, USA. Dobromir Dobrev Dresden University of Technology, Dresden, Germany. View the PDF of this article at: https://www.the-jci.org/article.php?id=37059 Karen Honey Journal of Clinical Investigation JCI online early table of contents: June 15, 2009


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