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CFIA Decodes Genetic Makeup Of H1N1 In Swine
Scientists at the Canadian Food Inspection Agency"s (CFIA) National Centre for Foreign Animal Disease (NCFAD) have mapped the full genetic sequence of the virus found in swine from Alberta-a development that will help scientists around the world better understand the virus and its affects on animals.
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Human Genome Sciences And GlaxoSmithKline Announce Positive Phase 3 Study Results For BENLYSTA(TM) In Systemic Lupus Erythematosus
Human Genome Sciences, Inc. (Nasdaq: HGSI) and GlaxoSmithKline PLC (GSK) announced that BENLYSTA(TM) (belimumab, formerly LymphoStat-B(R)) met the primary endpoint in BLISS-52, the first of two pivotal Phase 3 trials in patients with serologically active systemic lupus erythematosus (SLE). In the placebo-controlled BLISS-52 study, the results showed that belimumab plus standard of care achieved a clinically and statistically significant improvement in patient response rate at Week 52, compared with standard of care alone. Study results also showed that belimumab was generally well tolerated, with adverse event rates comparable between belimumab and placebo treatment groups.
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Coalition Commits To Addressing HIV/AIDS In Three U.S. Cities
The Global Business Coalition on HIV/AIDS, Tuberculosis and Malaria announced on Capitol Hill on Wednesday that it will help fight the spread of HIV in Washington D.C., New York City and Oakland, Calif., cities among the 20 areas in the U.S. with the highest rates of HIV and AIDS, the Washington Post reports. The coalition - which includes Pfizer, the National Basketball Association, Facebook, Nike, Nokia and others - said it will offer financial donations to city health departments, marketing expertise to promote prevention and treatment campaigns and appearances by professional basketball players for events, as part of their effort. John Newsome, a spokesperson for the coalition, said, "I think the ability of our corporate partners to help develop really effective messages, help provide res to get the message out, contribute talent, air time and media space" is crucial to HIV/AIDS awareness efforts. The coalition plans to expand the effort to other cities in the future (Fears, Washington Post, 6/25).
Cardiovascular

New Report Suggests That Zinc Activates A Key Protein On T Cells Needed To Fight Infections

Everyone knows that vitamins "from A to zinc" are important for good health. Now, a new research study in the August 2009 print issue of the Journal of Leukocyte Biology suggests that zinc may be pointing the way to new therapeutic targets for fighting infections. Specifically, scientists from Florida found that zinc not only supports healthy immune function, but increases activation of the cells (T cells) responsible for destroying viruses and bacteria. "It has been shown that zinc supplementation significantly reduces the duration and severity of childhood diarrhea, lower respiratory infections, and incidence of malaria in zinc-deficient children," said report co-author, Robert Cousins, Ph.D., who also is the director of the Center for Nutritional Sciences within the Food Science and Human Nutrition Department at the University of Florida. "Age-related declines in immune function have also been related to zinc deficiency in the elderly." Scientists administered either a zinc supplement or a placebo to healthy volunteers to assess the effects of zinc on T cell activation. After isolating the T cells from the blood, scientists then simulated infection in laboratory conditions. Results showed that T cells taken from the zinc-supplemented group had higher activation than those from the placebo group. Specifically, cell activation stimulated the zinc transporter in T cells called "ZIP8," which transports stored zinc into the cell cytoplasm where it then alters the expression of a T cell protein in a way needed to fight infections. "As the debate over zinc supplementation in healthy individuals continues," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, "studies like this help shed light on how zinc may enhance the ability of our immune systems to fight off foreign invaders. Equally important, this work points toward new possible targets for entirely new drugs to help augment immune function and prevent or stop infections that might be resistant to traditional antibiotics." Details: Tolunay B. Aydemir, Juan P. Liuzzi, Steve McClellan, and Robert J. Cousins Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN- expression in activated human T cells. J Leukoc Biol 2009 86: 337. http://www.jleukbio.org/cgi/content/abstract/86/2/337 Cody Mooneyhan Federation of American Societies for Experimental Biology


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