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When Managed By Specialty Pharmacy, MS Patients More Compliant With Medications
Multiple sclerosis patients managed by a specialty pharmacy program were more compliant with medication, and had a lower risk of being hospitalized for their disease than those who were not managed by a specialty pharmacy program, according to a study completed by HealthCore, Inc.

Clotting In Veins Close To Skin May Be Associated With More Dangerous Deep-Vein Blood Clots
About one-fourth of patients with superficial vein thrombosis-clotting in blood vessels close to the skin-also may have the life-threatening condition deep vein thrombosis, according to a report in the July issue of Archives of Dermatology, one of the JAMA/Archives journals.
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Liver Failure: Is Molecular Adsorbent Recirculating System Effective?
Since its introduction in 1993, molecular adsorbent recirculating system (MARS) albumin dialysis has been a subject of research, with the hope of effectively treating patients with acute liver failure. The impact of MARS treatment on outcome as well as clinical and laboratory variables has been investigated widely in small non-randomized studies. However, larger studies with longer follow-up time are required to determine the true usefulness of MARS treatment in different liver failure etiologies.
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Annals Of Internal Medicine Early Online Releases

Newly Designed Comprehensive Health Care Database May Advance Medical Research and Improve Patient Care High quality randomized clinical trials are not available to guide the clinical use of many therapies, so clinicians must rely on observational research. The AHRQ recently funded the development of the Distributed Ambulatory Research in Therapeutics Network, or DARTNet, to improve observational comparative effectiveness research and examine outcomes associated with prescription medications and medical devices. DARTNet is a federated network of electronic health data from eight organizations, representing more than 500 clinicians and 400,000 patients. A federated network links geographically and organizationally separate databases so that a single query can return results from multiple databases while also maintaining patient privacy. In addition to facilitating queries among the standardized and federated databases, the DARTNet system can prompt clinicians to obtain specific information during a patient visit. This capability allows the research team to collect additional data beyond what clinicians might routinely document in electronic records. Thus, DARTNet is designed to make available better data to enable high quality observational studies evaluating and comparing the effectiveness of various therapies. Researchers Describe the Structure and Benefits of a National Health Data Network If implemented, a national distributed health data network could become an important tool in the effort to improve the quality of health care. A distributed health data network is a system that allows secure, remote analysis of different medical organization or health plan datasets. In this type of network, organizations retain physical control over their data and its uses, allowing them to avoid issues related to confidentiality, regulation, and proprietary interests. Data from a national distributed health data network would cover many millions of people, which would have implications for studies pertaining to comparative effectiveness, best practices, diffusion of medical technologies, and quality of care. According to the researchers, there are considerable advantages to building a common core network to support the needs of multiple users, such as the FDA"s planned Sentinel System, the AHRQ"s DARTNet, and others, rather than building individual networks for each of these uses. The similarities in data needs and uses, coupled with potential savings of time and effort, favor a single, multi-purpose network. In closing, the authors caution that credible governance and funding mechanisms would be critical to ensure the long-term sustainability of the network. Angela Collom American College of Physicians


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